Squamous Cell Carcinoma Lung with Skeletal Muscle Involvement: A 8‑year Study of a Tertiary Care Hospital in Kashmir

Javvid Muzamil; Shumail Bashir; Faisal R Guru; Firdousa Nabi; Gull Mohammad Bhat

doi:10.4103/ijmpo.ijmpo_169_16

Indian Journal of Medical and Paediatric Oncology, Table of Contents

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(04): 456-460
DOI: 10.4103/ijmpo.ijmpo_169_16

Original Article

Squamous Cell Carcinoma Lung with Skeletal Muscle Involvement: A 8‑year Study of a Tertiary Care Hospital in Kashmir

Authors

Javvid Muzamil

Department of Medical Oncology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
Shumail Bashir

Department of Chest Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India
Faisal R Guru

Department of Medical Oncology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
Firdousa Nabi

Department of Prosthodonsia, Government Dental College, Srinagar, Jammu and Kashmir, India
Gull Mohammad Bhat

Department of Medical Oncology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India

Abstract

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Abstract

Aims: Lung cancer is the mostcommon malignancy throughout the world. Nonsmall cell lung cancer (NSCLC) is the mostcommon type, and squamous cell type is mostcommon in India. Mostly, patients present with chest-related symptoms and signs. Isolated skeletal muscle metastasis (ISMM) is rarely seen. The aim was to see muscle metastasis and its prognosis. Materials and Methods: We are presenting our data of 8 years about thiscommon malignancy with relation to muscle metastasis, either alone or with other system metastasis. Results: Muscle metastasis is seen 1.5% of patients, with male: female of 8:1. Overall median survival was 15 months and progression-free survival was 12 months. Conclusion: One peculiarity seen was ISMM with no pulmonary system and severe paraneoplastic hypercalcemia. Local therapy may be having an impact on overall survival in metachronous muscle involvement.

Keywords

Cytokeratin - isolated skeletal muscle metastasis - nonsmall cell lung carcinoma - overall survival - parathyroid hormone-related peptide - progression-free survival - superior vena cava - thyroid transcription factor

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References

References
1 Tuoheti Y, Okada K, Osanai T, Nishida J, Ehara S, Hashimoto M, et al. Skeletal muscle metastases of carcinoma: A clinicopathological study of 12 cases. Jpn J Clin Oncol 2004;34:210-4.
2 Pop D, Nadeemy AS, Venissac N, Guiraudet P, Otto J, Poudenx M,et al. Skeletal muscle metastasis from non-small cell lung cancer. J Thorac Oncol 2009;4:1236-41.
3 Di Giorgio A, Sammartino P, Cardini CL, Al Mansour M, Accarpio F, Sibio S,et al. Lung cancer and skeletal muscle metastases. Ann Thorac Surg 2004;78:709-11.
4 Kaira K, Ishizuka T, Yanagitani N, Sunaga N, Tsuchiya T, Hisada T,et al. Forearm muscle metastasis as an initial clinical manifestation of lung cancer. South Med J 2009;102:79-81.
5 McKeown PP, Conant P, Auerbach LE. Squamous cell carcinoma of the lung: An unusual metastasis to pectoralis muscle. Ann Thorac Surg 1996;61:1525-6.
6 Heyer CM, Rduch GJ, Zgoura P, Stachetzki U, Voigt E, Nicolas V, et al. Metastasis to skeletal muscle from esophageal adenocarcinoma. Scand J Gastroenterol 2005;40:1000-4.
7 Belhabib D, Maalej S, Fenniche S, Hassene H, Ammar A, Hantous S, et al. Muscle metastasis of a primary bronchial carcinoma. Tunis Med 2001;79:557-60.
8 Menard O, Seigneur J, Lamy P. Muscular metastasis of primary bronchial carcinoma. Rev Pneumol Clin 1990;46:183-6.
9 Cheong TH, Wang YT, Poh SC, Thung JL. Carcinoma of the lung with metastases to skeletal muscles. Singapore Med J 1989;30:605-6.
10 PRIOR C. Metastatic tumors in striated muscle; review and case report. Riv Anat Patol Oncol 1953;6:543-60.
11 Picken JW. Use and limitations of autopsy data. In: Weiss L, editor. Fundamental Aspects of Metastasis. Amsterdam: North-Holland; 1976. p. 377-84.
12 Heffernan E, Fennelly D, Collins CD. Multiple metastases to skeletal muscle from carcinoma of the esophagus detected by FDG PET-CT imaging. Clin Nucl Med 2006;31:810-1.
13 Liu Y, Ghesani N, Mirani N, Zuckier LS. PET-CT demonstration of extensive muscle metastases from breast cancer. Clin Nucl Med 2006;31:266-8.
14 Sridhar KS, Rao RK, Kunhardt B. Skeletal muscle metastases from lung cancer. Cancer 1987;59:1530-4.
15 Toussirot E, Lafforgue P, Tonolli I, Acquaviva PC. Disclosing muscular metastases. Their peculiarities apropos of 3 cases. Rev Rhum Ed Fr 1993;60:167-71.
16 Weiss L. Biomechanical destruction of cancer cells in skeletal muscle: A rate-regulator for hematogenous metastasis. Clin Exp Metastasis 1989;7:483-91.
17 Seely S. Possible reasons for the high resistance of muscle to cancer. Med Hypotheses 1980;6:133-7.
18 Zhang P, Meng X, Xia L, Xie P, Sun X, Gao Y,et al. Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review. Oncol Lett 2015;10:3059-63.