Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(01): 90-93
DOI: 10.4103/ijmpo.ijmpo_164_18
Original Article

Trends in gallbladder cancer incidence in the high- and low-risk regions of India

Prachi Ravindra Phadke
Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India
Centre for Cancer Epidemiology, Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Sharayu Sitaram Mhatre
Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India
,
Atul Madhukar Budukh
Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India
,
Rajesh Prabhakar Dikshit
Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, Maharashtra, India
Centre for Cancer Epidemiology, Homi Bhabha National Institute, Mumbai, Maharashtra, India
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
   Permissions and Reprints

Abstract

Background: Gallbladder cancer (GBC), a common cancer surrounding the Gangetic belt of India, accounts for 80%–90% of biliary tract cancers. GBC incidence shows striking geographical variation in India. Materials and Methods: We used the data from the National Cancer Registry Programme for the year 2001–2014 to study the time trends of GBC in the high- and low-risk geographical regions of India. Annual percentage change (APC) in age-adjusted incidence rates was computed by log-linear regression model. Results: Among females, a statistically significant increase in trend was observed in Cachar (APC: 7.0, P = 0.02), Delhi (APC: 4.0, P = 0.04), and Kamrup (APC: 4.3, P = 0.02) marked under high-risk region and in Bengaluru (APC: 5.7, P = 0.04) and Pune (APC: 3.4, P = 0.04) marked under low-risk region. Among males, increasing but statistically nonsignificant trends were observed in Cachar, Dibrugarh, Kamrup, Nagpur, and Sikkim, whereas decreasing trends were observed in Bengaluru, Barshi, Bhopal, and Kolkata. Aurangabad showed a statistically significant decrease in trend (APC: −14.5, P < 0.001) among males. Conclusion: The time trend and pattern of GBC have striking differences within the country as well as in state. Further large-scale region-wise studies are needed to find the risk factors of GBC.

Keywords

Gallbladder cancer - incidence rate - India - trend


Publication History

Article published online:
08 June 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Globocan 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide by International Agency for Research on Cancer. Available from: http://www.globocan.iarc.fr/. [Last accessed on 2018 Nov 01].
  • 2 Mhatre SS, Nagrani RT, Budukh A, Chiplunkar S, Badwe R, Patil P. et al. Place of birth and risk of gallbladder cancer in India. Indian J Cancer 2016; 53: 304-8
    CrossrefPubMedGoogle Scholar
  • 3 National Cancer Registry Programme by Indian Council of Medical Research. Available from: http://www.ncrpindia.org/. [Last accessed on 2018 Nov 01].
  • 4 Joinpoint Trend Analysis Software (Version 4.6.0.0) by National Cancer Institute. Available from: https://www.surveillance.cancer.gov/joinpoint/. [Last accessed on 2018 Nov 01].
  • 5 Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med 2000; 19: 335-51
    CrossrefPubMedGoogle Scholar
  • 6 Mhatre S, Wang Z, Nagrani R, Badwe R, Chiplunkar S, Mittal B. et al. Common genetic variation and risk of gallbladder cancer in India: A case-control genome-wide association study. Lancet Oncol 2017; 18: 535-44
    CrossrefPubMedGoogle Scholar
  • 7 Mhatre S, Chatterjee N, Dikshit R, Rajaraman P. et al. Genetics of gallbladder cancer – Authors' reply. Lancet Oncol 2017; 18: e97
    CrossrefPubMedGoogle Scholar
  • 8 Misra S, Chaturvedi A, Misra NC, Sharma ID. Carcinoma of the gallbladder. Lancet Oncol 2003; 4: 167-76
    CrossrefPubMedGoogle Scholar
  • 9 Randi G, Franceschi S, La VecchiaC. Gallbladder cancer worldwide: Geographical distribution and risk factors. Int J Cancer 2006; 118: 1591-602
    CrossrefPubMedGoogle Scholar
  • 10 Hundal R, Shaffer EA. Gallbladder cancer: Epidemiology and outcome. Clin Epidemiol 2014; 6: 99-109
    Google Scholar