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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(04): 452-455
DOI: 10.4103/ijmpo.ijmpo_153_16
Original Article

Oral Verrucous Carcinoma: Ten Year Experience from a Tertiary Care Hospital in India

Joshua Franklyn
Department of General Surgery Unit 1 (Including Head and Neck Surgery), Paul Brand Building, Christian Medical College, Vellore, Tamil Nadu, India
,
Rajinikanth Janakiraman
Department of General Surgery Unit 1 (Including Head and Neck Surgery), Paul Brand Building, Christian Medical College, Vellore, Tamil Nadu, India
,
Amit J Tirkey
Department of General Surgery Unit 1 (Including Head and Neck Surgery), Paul Brand Building, Christian Medical College, Vellore, Tamil Nadu, India
,
Cecil Thankachan
Department of General Surgery Unit 1 (Including Head and Neck Surgery), Paul Brand Building, Christian Medical College, Vellore, Tamil Nadu, India
,
John Muthusami
Department of General Surgery Unit 1 (Including Head and Neck Surgery), Paul Brand Building, Christian Medical College, Vellore, Tamil Nadu, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Background: Verrucous carcinoma of the oral cavity (OVC) is an uncommon variant of oral squamous cell carcinoma (OSCC). The clinical presentation and surgical outcomes of OVC are unique; however, the management protocols for OVC are largely extrapolated from OSCC. Objectives: The aim is to study the clinical, histopathological demographics, and outcome of OVC at a tertiary care referral hospital in South India. To study the need for lymph node dissection and the role of adjuvant therapy for close resection margins. Materials and Methods: A retrospective review of all patients diagnosed to have OVC between January 2005 and April 2015 was undertaken. Data were collected from hospital records and telephonic interview when possible. Results: Thirty patients were diagnosed to have OVC. The mostcommon site of the presentation was the buccal mucosa. Twenty-three patients had wide local excision of the primary tumor and seven patients had neck dissection as well. None of the patients who underwent neck dissection had node-positive disease pathologically. The margins were considered close in nine patients, only one of these patients received adjuvant radiation therapy; despite among the patients with close resection margins, there was no recurrence or disease-related mortality. Among the thirty patients, there was only one patient who had recurred locally and there was no disease associated mortality. Conclusions: OVC is a unique variant of OSCC which has a good prognosis. Routine lymphadenectomy can be avoided.

Keywords

India - oral cancer - verrucous carcinoma


Publication History

Article published online:
04 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used forcommercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Rekha KP, Angadi PV. Verrucous carcinoma of the oral cavity: A clinico-pathologic appraisal of 133 cases in Indians. Oral Maxillofac Surg 2010;14:211-8.
  • 2 Alkan A, Bulut E, Gunhan O, Ozden B. Oral verrucous carcinoma: A study of 12 cases. Eur J Dent 2010;4:202-7.
  • 3 Terada T. Verrucous carcinoma of the oral cavity: A histopathologic study of 10 Japanese cases. J Maxillofac Oral Surg 2011;10:148-51.
  • 4 Walvekar RR, Chaukar DA, Deshpande MS, Pai PS, Chaturvedi P, Kakade A, et al. Verrucous carcinoma of the oral cavity: A clinical and pathological study of 101 cases. Oral Oncol 2009;45:47-51.
  • 5 AJCC Cancer Staging Manual | Springer. Available from: http://www.springer.com/in/book/9780387884400. [Last accessed on 2015 Jun 22].
  • 6 Jordan RC. Verrucous carcinoma of the mouth. J Can Dent Assoc 1995;61:797-801.
  • 7 Sadasivan A, Thankappan K, Rajapurkar M, Shetty S, Sreehari S, Iyer S, et al. Verrucous lesions of the oral cavity treated with surgery: Analysis of clinico-pathologic features and outcome. Contemp Clin Dent 2012;3:60-3.
  • 8 Gokavarapu S, Chandrasekhara Rao LM, Patnaik SC, Parvataneni N, Raju KV, Chander R, et al. Reliability of incision biopsy for diagnosis of oral verrucous carcinoma: A Multivariate clinicopathological study. J Maxillofac Oral Surg 2015;14:599-604.
  • 9 Garcia NG, Oliveira DT, Hanemann JA, Pereira AA. Oral verrucous carcinoma mimicking a chronic candidiasis: A case report. Case Rep Oncol Med 2012;2012:190272.
  • 10 Mehrotra D, Goel M, Kumar S, Pandey R, Ram H. Oral verrucous lesions: Controversies in diagnosis and management. J Oral Biol Craniofac Res 2012;2:163-9.
  • 11 Depprich RA, Handschel JG, Fritzemeier CU, Engers R, Kübler NR. Hybrid verrucous carcinoma of the oral cavity: A challenge for the clinician and the pathologist. Oral Oncol Extra 2006;42:85-90.
  • 12 Huang SH, Lockwood G, Irish J, Ringash J, Cummings B, Waldron J, et al. Truths and myths about radiotherapy for verrucous carcinoma of larynx. Int J Radiat Oncol Biol Phys 2009;73:1110-5.
  • 13 Devaney KO, Ferlito A, Rinaldo A, El-Naggar AK, Barnes L. Verrucous carcinoma (carcinoma cuniculatum) of the head and neck: What do we know now that we did not know a decade ago? Eur Arch Otorhinolaryngol 2011;268:477-80.
  • 14 Nason RW, Binahmed A, Pathak KA, Abdoh AA, Sándor GK. What is the adequate margin of surgical resection in oral cancer? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:625-9.
  • 15 Eldeeb H, Macmillan C, Elwell C, Hammod A. The effect of the surgical margins on the outcome of patients with head and neck squamous cell carcinoma: Single institution experience. Cancer Biol Med 2012;9:29-33.
  • 16 Dillon JK, Brown CB, McDonald TM, Ludwig DC, Clark PJ, Leroux BG, et al. How does the close surgical margin impact recurrence and survival when treating oral squamous cell carcinoma? J Oral Maxillofac Surg 2015;73:1182-8.
  • 17 Candau-Alvarez A, Dean-Ferrer A, Alamillos-Granados FJ, Heredero-Jung S, García-García B, Ruiz-Masera JJ, et al. Verrucous carcinoma of the oral mucosa: An epidemiological and follow-up study of patients treated with surgery in 5 last years. Med Oral Patol Oral Cir Bucal 2014;19:e506-11.
  • 18 Wang B, Zhang S, Yue K, Wang XD. The recurrence and survival of oral squamous cell carcinoma: A report of 275 cases. Chin J Cancer 2013;32:614-8.
  • 19 Oral Cancer 5-Year Survival Rates by Race, Gender, and Stage of Diagnosis. Available from: http://www.nidcr.nih.gov/DataStatistics/FindDataByTopic/OralCancer/OralCancer5 YearSurvivalRates.htm. [Last accessed on 2015 Oct 05].