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DOI: 10.4103/ijmpo.ijmpo_146_20
Primary Ependymoma of the Ovary Mimicking as Yolk Sac Tumor: A Rare Case Report
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Abstract
Ependymoma is a glioma with the differentiation toward ependymal cells that usually arise in the central nervous system. Primary ovarian ependymoma is a rare gynecologic malignancy, of which very few cases have been published. Here, we present the case of a 21-year-old woman who presented with a pelvic mass. Ultrasonography revealed a solid cystic mass in the left adnexa. The patient underwent left oophorectomy followed by cytoreductive completion surgery. On histopathological examination, a possibility of primary glial and neuronal tumor of the ovary was made. The final diagnosis of primary ependymoma of the ovary was arrived upon due to strong positivity for glial fibrillary acidic protein and S100, along with positivity for pancytokeratin, epithelial membrane antigen, vimentin, estrogen receptor, and progesterone receptor on immunohistochemistry. Although a rare diagnosis, when presented with an ovarian mass in a young patient, this diagnosis must be borne in mind.
Publication History
Received: 09 April 2020
Accepted: 09 June 2020
Article published online:
17 May 2021
© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
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References
- 1 Idowu MO, Rosenblum MK, Wei X, Edgar MA, Soslow RA. Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct-A comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein. Am J Surg Pathol 2008; 32: 710-18
- 2 Bell DA, Woodruff JM, Scully RE. Ependymoma of the broad ligament. A report of two cases. Am J Surg Pathol 1984; 8: 203-9
- 3 Doglioni C, Bontempini L, Iuzzolino P, Furlan G, Rosai J. Ependymoma of the mediastinum. Arch Pathol Lab Med 1988; 112: 194-6
- 4 Prat J, Cao D, Carinelli SG, Nogales FF, Vang R, Zaloudek CJ. Monodermal teratomas and somatic type tumours arising from a dermoid cyst. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH. editors WHO Classification of Tumours of Female Reproductive Organs. 4th ed. Lyon: IARC; 2014: 64-5
- 5 Hirahara F, Yamanaka M, Miyagia E, Nakazawa T, Gorai I, Minaguchi H. et al. Pure ovarian ependymoma: Report of a case treated with surgery, chemotherapy, irradiation and hyperthermotherapy. Eur J Obstet Gynecol Reprod Biol 1997; 75: 221-3
- 6 Carr KA, Roberts JA, Frank TS. Progesterone receptors in bilateral ovarian ependymoma presenting in pregnancy. Hum Pathol 1992; 23: 962-5
- 7 Yust Katz S, Cachia D, Kamiya-Matsuoka C, Olar A, Theeler B, Penas Prado M. et al. Ependymomas arising outside of the central nervous system: A case series and literature review. J Clin Neurosci 2018; 47: 202-7
- 8 Kleinman GM, Young RH, Scully RE. Primary neuroectodermal tumors of the ovary. A report of 25 cases. Am J Surg Pathol 1993; 17: 764-78
- 9 Liang L, Olar A, Niu N, Jiang Y, Cheng W, Bian XW. et al. Primary glial and neuronal tumors of the ovary or peritoneum: A clinicopathologic study of 11 cases. Am J Surg Pathol 2016; 40: 847-56
- 10 Stolnicu S, Furtado A, Sanches A, Nicolae A, Preda O, Hincu M. et al. Ovarian ependymomas of extra-axial type or central immunophenotypes. Human Pathol 2011; 42: 403-8
- 11 Gorski JW, Taylor JS, Zhang J, Liu J, Jazaeri AA. Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole. Gynecol Oncol Rep 2017; 20: 93-6