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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(04): 608-611
DOI: 10.4103/ijmpo.ijmpo_137_19
Practitioner Section

Takatsuki Syndrome – Not Really a Polyneuropathy, Organomegaly, Endocrinopathy, M-spike, and Skin Change!!!

Vashe Keshava Vineeth
Department of General Medicine, Unit 1V, Christian Medical College, Vellore, Tamil Nadu, India
,
Vijith Shetty
Department of Medical Oncology, K. S. Hegde Medical Academy, NITTE Deemed to be University, Deralakatte, Karnataka, India
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Abstract

Polyneuropathy, organomegaly, endocrinopathy, M-spike, and skin changes (POEMS) is a rare multisystem disorder, with its prevalence in India being 1 in 330,000. It is a demyelinating neuropathy accompanied by dermatoendocrine syndrome. The cause of POEMS is unknown. The diagnosis of POEMS syndrome requires two mandatory criteria plus more than one major and more than one minor criterion. A middle-aged male with no known comorbidities from South India presented with complaints of burning micturition, increased frequency of micturition, and pain in the abdomen for 3 weeks. The patient was evaluated earlier at another center with a rise in serum creatinine from 1.9 to 2.9 mg/dl within a span of 3 days. The patient had pleural effusion, hypercalcemia, renal failure, and splenomegaly with lytic lesions. Due to the presence of typical skin lesions with polyneuropathy, workup for POEMS was carried out. Positron-emission tomography scan and vascular endothelial growth factor levels were checked and fulfilled the criteria. Early treatment was initiated, and POEMS has a good prognosis. As POEMS is very rare, early diagnosis improves the outcome.

Keywords

Multiple myeloma - POEMS - skin changes - vascular endothelial growth factor


Publikationsverlauf

Eingereicht: 09. Juni 2019

Angenommen: 19. Januar 2020

Artikel online veröffentlicht:
17. Mai 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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