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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(02): 206-209
DOI: 10.4103/ijmpo.ijmpo_132_17
Original Article

Epstein–Barr Virus Infection in Adult Patients with Gastric Cancer in Northeast of Iran

Sakineh Amoueian
Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
,
Armin Attaranzadeh
Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
,
Zeinab Gholamimoallem
Department of Hematology and Medical Oncology, Mashhad University of Medical Sciences, Mashhad, Iran
,
Masoud Sadeghi
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
,
Seyed-Mehdi Hashemi
Department of Hematology and Medical Oncology, Zahedan University of Medical Sciences, Zahedan, Iran
,
Abolghasem Allahyari
Department of Hematology and Medical Oncology, Mashhad University of Medical Sciences, Mashhad, Iran
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Background: Epstein–Barr virus (EBV) is a DNA virus from human herpes virus that associates with many of the human cancers including gastric cancer (GC). Aims: The aim of the present study was to report infection of EBV in adult patients with GC in Northeast of Iran and the correlation between a number of clinicopathology factors with EBV status. Materials and Methods: In a case–control study in 2016, 56 GC patients and 56 controls were selected for the analysis. All patients had gastric adenocarcinoma untreated patients with age >18 years. EBV status detected by the polymerase chain reaction method. Results: Out of 56 GC patients, 35 (62.5%) were EBV positivity and out of 56 controls 3 (5.4%) were EBV positivity (P < 0.001). There is not a significant correlation between the variables with the EBV status (P > 0.05). Furthermore, the progression-free survival rate for the patients with EBV negativity was 95.2% compared with 82.9% for EBV positivity (P = 0.174). Conclusions: This study reported a very high prevalence of EBV-associated GC in the Northeast of Iran compared with other areas of the World and showed a significant correlation between EBV infection and incidence of GC.

Keywords

Epstein–Barr virus - gastric cancer - polymerase chain reaction - survival


Publication History

Article published online:
23 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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