CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(04): 499-502
DOI: 10.4103/ijmpo.ijmpo_126_17
Review Article

Use of Organoids Technology on Study of Liver Malignancy

Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok, Thailand
,
Viroj Wiwanitkit
Department of Biological Science, Joseph Ayo Babalola University, Ilara-Mokin, Nigeria
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

The study on liver cancer has been performed in clinical medicine and medical science for a long time. Within the few recent years, there are many new emerging biomedical technologies that help better assess on the liver cancer. Of several new technologies, the advanced cell technologies for the assessment of liver cancer, organoids technology is very interesting. In fact, the organoids is an advanced cell research technique that can be useful for studying of many medical disorders. Organoids can be applied for study on the pathophysiology of many cancers. The application for studying on liver cancer is very interesting issue in hepatology. In this short article, the author summarizes and discusses on applied organoids technology for studying on various kinds of liver cancers. The application can be seen on primary hepatocellular carcinoma, metastatic cancer, cholangiocarcinoma, hepatoblastoma, as well as other rare liver cancers.



Publication History

Article published online:
17 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Simunovic M, Brivanlou AH. Embryoids, organoids and gastruloids: New approaches to understanding embryogenesis. Development 2017; 144: 976-85
  • 2 Dormoy V, Jacqmin D, Lang H, Massfelder T. From development to cancer: Lessons from the kidney to uncover new therapeutic targets. Anticancer Res 2012; 32: 3609-17
  • 3 Dahl-Jensen S, Grapin-Botton A. The physics of organoids: A biophysical approach to understanding organogenesis. Development 2017; 144: 946-51
  • 4 Clevers H. Modeling development and disease with organoids. Cell 2016; 165: 1586-97
  • 5 Schaper J. Effects of multiple ischaemic events on human myocardium – An ultrastructural study. Eur Heart J 1988; 9 Suppl A 141-9
  • 6 Date S, Sato T. Mini-gut organoids: Reconstitution of the stem cell niche. Annu Rev Cell Dev Biol 2015; 31: 269-89
  • 7 Giandomenico SL, Lancaster MA. Probing human brain evolution and development in organoids. Curr Opin Cell Biol 2017; 44: 36-43
  • 8 Morizane R, Bonventre JV. Kidney organoids: A translational journey. Trends Mol Med 2017; 23: 246-63
  • 9 Ruggiu A, Cancedda R. Bone mechanobiology, gravity and tissue engineering: Effects and insights. J Tissue Eng Regen Med 2015; 9: 1339-51
  • 10 Barkauskas CE, Chung MI, Fioret B, Gao X, Katsura H, Hogan BL. Lung organoids: Current uses and future promise. Development 2017; 144: 986-97
  • 11 Hindley CJ, Cordero-Espinoza L, Huch M. Organoids from adult liver and pancreas: Stem cell biology and biomedical utility. Dev Biol 2016; 420: 251-61
  • 12 Jones JR, Zhang SC. Engineering human cells and tissues through pluripotent stem cells. Curr Opin Biotechnol 2016; 40: 133-8
  • 13 Xu AT, Tong JL, Ran ZH. Organoids derived from digestive tract, liver, and pancreas. J Dig Dis 2016; 17: 3-10
  • 14 Mitaka T. Reconstruction of hepatic organoid by hepatic stem cells. J Hepatobiliary Pancreat Surg 2002; 9: 697-703
  • 15 Mitaka T, Ooe H. Characterization of hepatic-organoid cultures. Drug Metab Rev 2010; 42: 472-81
  • 16 Gao D, Chen Y. Organoid development in cancer genome discovery. Curr Opin Genet Dev 2015; 30: 42-8
  • 17 Hemming AW, Berumen J, Mekeel K. Hepatitis B and hepatocellular carcinoma. Clin Liver Dis 2016; 20: 703-20
  • 18 Colpitts CC, Verrier ER, Baumert TF. Targeting viral entry for treatment of hepatitis B and C virus infections. ACS Infect Dis 2015; 1: 420-7
  • 19 Sacramento CQ, de Melo GR, de Freitas CS, Rocha N, Hoelz LV, Miranda M. et al. The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication. Sci Rep 2017; 7: 40920
  • 20 Wiwanitkit V. Organoids as a tool for hepatoma research. J Cancer Res Ther 2017. [In press].
  • 21 Drost J, Clevers H. Translational applications of adult stem cell-derived organoids. Development 2017; 144: 968-75
  • 22 Saito M, Matsuura T, Masaki T, Maehashi H, Shimizu K, Hataba Y. et al. Reconstruction of liver organoid using a bioreactor. World J Gastroenterol 2006; 12: 1881-8
  • 23 Kobayashi A, Yamakoshi K, Yajima Y, Utoh R, Yamada M, Seki M. Preparation of stripe-patterned heterogeneous hydrogel sheets using microfluidic devices for high-density coculture of hepatocytes and fibroblasts. J Biosci Bioeng 2013; 116: 761-7
  • 24 Crosas-Molist E, Bertran E, Rodriguez-Hernandez I, Herraiz C, Cantelli G, Fabra À. et al. The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination. Oncogene 2017; 36: 3002-14
  • 25 Yip D, Cho CH. A multicellular 3D heterospheroid model of liver tumor and stromal cells in collagen gel for anti-cancer drug testing. Biochem Biophys Res Commun 2013; 433: 327-32
  • 26 Lu J, Zhang Y, Sun M, Liu M, Wang X. Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine 2017; 26: 1-10
  • 27 Skardal A, Devarasetty M, Rodman C, Atala A, Soker S. Liver-tumor hybrid organoids for modeling tumor growth and drug response in vitro. Ann Biomed Eng 2015; 43: 2361-73
  • 28 Xie BY, Wu AW. Organoid culture of isolated cells from patient-derived tissues with colorectal cancer. Chin Med J (Engl) 2016; 129: 2469-75
  • 29 Wilcox BA, Echaubard P. Balancing biomedical and ecological perspectives in research framing of liver fluke and cholangiocarcinoma in NE Thailand. Parasitol Int 2017; 66: 372-77
  • 30 Zheng S, Zhu Y, Zhao Z, Wu Z, Okanurak K, Lv Z. et al. Liver fluke infection and cholangiocarcinoma: A review. Parasitol Res 2017; 116: 11-9
  • 31 Kosaka T, Tsuboi S, Fukaya K, Pu H, Ohno T, Tsuji T. et al. Spheroid cultures of human hepatoblastoma cells (HuH-6 line) and their application for cytotoxicity assay of alcohols. Acta Med Okayama 1996; 50: 61-6
  • 32 Zheng J, Hou Y, Zhou R, Zhong D. Clinicopathological features of primary hepatic diffuse large B-cell lymphoma: A report of seven cases and a literature review. Int J Clin Exp Pathol 2015; 8: 12955-60
  • 33 Tian YF, Ahn H, Schneider RS, Yang SN, Roman-Gonzalez L, Melnick AM. et al. Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells. Biomaterials 2015; 73: 110-9