Colonic Metastases from a Luminal A Type Invasive Ductal Carcinoma Breast: A Rare Case Report

Abstract

Metastatic carcinoma breast involving hepatobiliary system and peritoneum is a common and well-described entity. However, colonic luminal involvement by breast metastases is rare and its early recognition is important for accurate management planning. We report a case of an elderly woman with luminal A type invasive ductal carcinoma (IDC) breast, initially controlled/stabilized on hormonal treatment and later progressed to involve colon presenting with intestinal obstructive symptoms. Lobular carcinoma breast which constitutes around 10% of breast cancers is more likely to have gastrointestinal tract (GIT) involvement. On the other hand, GIT metastasis from IDC breast is quite rare. Given the progressively increasing survival with current and forthcoming novel treatment modalities, it is very important to recognize and understand unusual presentation of metastatic breast cancer, such as colonic metastasis, for timely treatment planning and implementation.

Keywords

Carcinoma breast - colonic metastases - invasive ductal carcinoma - unusual metastasis

Publication History

Received: 09 May 2018

Accepted: 21 June 2018

Article published online:
23 May 2021

• References

• 1 Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M. et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136: E359-86
• 2 Largillier R, Ferrero JM, Doyen J, Barriere J, Namer M, Mari V. et al. Prognostic factors in 1,038 women with metastatic breast cancer. Ann Oncol 2008; 19: 2012-9
• 3 Leone JP, Lee AV, Brufsky AM. Prognostic factors and survival of patients with brain metastasis from breast cancer who underwent craniotomy. Cancer Med 2015; 4: 989-94
• 4 Brogi E, Murphy CG, Johnson ML, Conlin AK, Hsu M, Patil S. et al. Breast carcinoma with brain metastases: Clinical analysis and immunoprofile on tissue microarrays. Ann Oncol 2011; 22: 2597-603
• 5 Uygun K, Kocak Z, Altaner S, Cicin I, Tokatli F, Uzal C. Colonic metastasis from carcinoma of the breast that mimics a primary intestinal cancer. Yonsei Med J 2006; 47: 578-82
• 6 McLemore EC, Pockaj BA, Reynolds C, Gray RJ, Hernandez JL, Grant CS. et al. Breast cancer: Presentation and intervention in women with gastrointestinal metastasis and carcinomatosis. Ann Surg Oncol 2005; 12: 886-94
• 7 Critchley AC, Harvey J, Carr M, Iwuchukwu O. Synchronous gastric and colonic metastases of invasive lobular breast carcinoma: Case report and review of the literature. Ann R Coll Surg Engl 2011; 93: e49-50
• 8 Joffe N. Metastatic involvement of the stomach secondary to breast carcinoma. Am J Roentgenol Radium Ther Nucl Med 1975; 123: 512-21
• 9 Cifuentes N, Pickren JW. Metastases from carcinoma of mammary gland: An autopsy study. J Surg Oncol 1979; 11: 193-205
• 10 Nazareno J, Taves D, Preiksaitis HG. Metastatic breast cancer to the gastrointestinal tract: A case series and review of the literature. World J Gastroenterol 2006; 12: 6219-24
• 11 Fujimoto D, Hirono Y, Goi T, Yamaguchi A. Sigmoid colonic metastasis by lymphatic spread occurring with unilateral krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report. Oncol Lett 2016; 11: 668-72
• 12 Villa Guzmán JC, Espinosa J, Cervera R, Delgado M, Patón R, Cordero García JM. Gastric and colon metastasis from breast cancer: Case report, review of the literature, and possible underlying mechanisms. Breast Cancer (Dove Med Press) 2017; 9: 1-7
• 13 Birla R, Mahawar KK, Orizu M, Siddiqui MS, Batra A. Caecal metastasis from breast cancer presenting as intestinal obstruction. World J Surg Oncol 2008; 6: 47
• 14 Li X, Schwartz MR, Ro J, Hamilton CR, Ayala AG, Truong LD. et al. Diagnostic utility of E-cadherin and P120 catenin cocktail immunostain in distinguishing DCIS from LCIS. Int J Clin Exp Pathol 2014; 7: 2551-7