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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(03): 321-325
DOI: 10.4103/ijmpo.ijmpo_109_17
Original Article

Assessment of Angiogenesis in Children with Acute Lymphoblastic Leukemia Based on Serum Vascular Endothelial Growth Factor Assay

Agnieszka Mizia-Malarz
Department of Paediatric Oncology, Haematology and Chemotherapy, Upper Silesian Children's Healthcare Centre, Medical University of Silesia, Katowice, Poland
,
Grazyna Sobol-Milejska
Department of Paediatric Oncology, Haematology and Chemotherapy, Upper Silesian Children's Healthcare Centre, Medical University of Silesia, Katowice, Poland
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Introduction: Vascular endothelial growth factor A (VEGFA) is a key proangiogenic cytokine. The role of angiogenesis in acute lymphoblastic leukemia (ALL) is still unclear. The purpose of the study was to assess angiogenesis in children with ALL based on serum VEGFA level determined at diagnosis and at remission with further participant subdivision into different risk groups. Materials and Methods: Forty children, aged 3–12 years (mean age: 8 years) with newly diagnosed ALL, were enrolled in the study. The control group (Group C) was twenty healthy children. According to the risk assessment, they were classified into a standard-risk group, an intermediate-risk group (IRG), or a high-risk group (HRG). Results: The median serum VEGFA levels at diagnosis were significantly higher in IRG and HRG as compared to Group C. The VEGFA levels at remission were significantly higher in all study groups, as compared to Group C. The differences in median values of serum VEGFA levels between the study groups both at diagnosis and at remission were not statistically significant. Conclusions: The angiogenesis in ALL seems to be intensified at diagnosis as a result of neoplasmatic bone marrow rebuilding and at remission as its intensive recovering.

Keywords

Acute lymphoblastic leukemia - angiogenesis - children - vascular endothelial growth factor


Publication History

Article published online:
04 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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