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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(05): 748-751
DOI: 10.4103/ijmpo.ijmpo_100_20
Case Report and Review of Literature

Histiocytoid Sweet Syndrome: A Rare Variant of Classic Paraneoplastic Dermatosis in Relation to Myelodysplastic Syndrome - A Case Report

Tanvi Dev
1   Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
,
Shipra Agarwal
2   Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
,
Sujay Khandpur
1   Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Histiocytoid Sweet syndrome is a distinctive variant of Sweet syndrome, which is more frequently associated with myelodysplastic syndromes (MDS) than the latter. We describe a 59-year-old woman, diagnosed with MDS 4 months back, who developed sudden onset of rapidly progressing multiple painful erythematous papules and plaques on bilateral forearms, without any systemic complaints. The biopsy revealed interstitial and perivascular infiltrate of immature histiocytoid cells (positive for CD 68, myeloperoxidase, lysozyme, and CD15), along with papillary dermal edema. The eruption resolved with topical steroids in 3 weeks.

Keywords

Histiocytoid Sweet syndrome - myelodysplastic syndrome - paraneoplastic dermatoses


Publication History

Received: 19 March 2020

Accepted: 14 May 2020

Article published online:
17 May 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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