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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2018; 10(03): 94-98
DOI: 10.4103/ijmbs.ijmbs_62_17
Original Article

Primary gastric lymphoma: A study of morphology, immunophenotype, and prevalence of Helicobacter pylori infection

Mohamed Elmoaket
1   Department of Pathology, Tripoli Medical Center
2   Judicial Expertise and Research Center, Tripoli
,
Fatma Emaetig
3   Department of Pathology, Faculty of Medicine, Benghazi University, Benghazi
4   Department of Pathology, Faculty of Medicine, Misurata University, Misurata
,
Firas Abdulmalik
5   Department of Pathology, Misurata Cancer Center, Misurata
,
Fairouz Torjman
1   Department of Pathology, Tripoli Medical Center
6   Department of Pathology, Faculty of Medicine, Tripoli University, Tripoli
,
Nabil Enattah
7   Department of Genetic Engineering, Biotechnology Research Center, Tripoli
,
Adam ElZagheid
3   Department of Pathology, Faculty of Medicine, Benghazi University, Benghazi
7   Department of Genetic Engineering, Biotechnology Research Center, Tripoli
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Objectives: We aimed to study the pattern of primary gastric lymphoma in two geographically different locations, namely, Tripoli Medical Center (TMC) in Libya and Antwerp University Hospital (Universitair Ziekenhuis Antwerpen [UZA]) in Belgium. Materials and methods: Twenty-four cases of primary gastric lymphoma diagnosed during an 8-year period at TMC and 20 cases diagnosed during 11-year period in UZA were studied. Immunohistochemistry lymphoma panel CD3, CD5, CD20, CD10, CD79a, CyclinD1, KI67, and pancytokeratin were applied in all cases. Results: Primary gastric lymphoma in UZA occurs in a slightly older age group with marked male predominance while in TMC occurs at a slightly younger age with marginal male predominance. Two-thirds of the TMC cases were of high-grade lymphoma (HGL) and one-third were low-grade lymphoma (LGL). UZA cases included nine cases of HGL with (45%) and 11 of LGL (55%). Of the TMC primary gastric lymphoma cases, 12 were infected with Helicobacter pylori (50%) and eight cases were mucosa-associated lymphoid tissue lymphoma (MALT-L) of which three cases had H. pylori infection. In the UZA cases, H. pylori infection was evident in seven of 20 primary gastric lymphoma cases (35%) and three of six MALT-L had H. pylori-infected cases (50%). Conclusions: This comparative study of primary gastric lymphoma in TMC (Libyan) and UZA (Belgian) studied cases showed no marked differences between the two patient populations based on the histological features and immunohistochemical phenotype and genotype and the clinical features.

Key-words:

Helicobacter pylori - immunohistochemistry - primary gastric lymphoma


Publication History

Article published online:
07 July 2022

© 2018. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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