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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2019; 11(04): 188-191
DOI: 10.4103/ijmbs.ijmbs_53_19
Case Report

Hepatitis A-associated cholestasis and aplastic anemia

Amal Elarabi
1   Department of Paediatric Gastroenterology and Hepatology, Tripoli University Hospital, Tripoli
,
Zinab Saad
1   Department of Paediatric Gastroenterology and Hepatology, Tripoli University Hospital, Tripoli
2   Department of Paediatric, Faculty of Medicine, University of Tripoli, Tripoli
,
Fauzi Sagher
1   Department of Paediatric Gastroenterology and Hepatology, Tripoli University Hospital, Tripoli
2   Department of Paediatric, Faculty of Medicine, University of Tripoli, Tripoli
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Hepatitis A virus (HAV) infection in children is typically an acute, self-limited illness associated with general, nonspecific symptoms. Prolonged cholestasis is a rare atypical form of HAV infection that is characterized by serum bilirubin levels higher than 10 mg/dl for more than 12 weeks. Aplastic anemia is another very rare complication of HAV. We report the case of an 11-year-old male with blood group O Rh positive who developed cholestasis followed by aplastic anemia postfulminant HAV infection. Liver function tests rapidly responded to a short course of steroid treatment. The patient had a sickle cell trait and a variant of ABCB11 gene. There was no history of traditional herbal treatment, but we noticed several cautery marks. Immunosuppressive medication was started for aplastic anemia, and he is listed for urgent bone marrow transplant. This is the first reported case of prolonged cholestasis followed by aplastic anemia complicating fulminant HAV infection in a Libyan adolescent.

Key-words:

Aplastic anemia - cholestasis - hepatitis A

Financial support and sponsorship

Nil.




Publication History

Received: 09 September 2019

Accepted: 12 November 2019

Article published online:
07 July 2022

© 2019. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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