Hepatitis A-associated cholestasis and aplastic anemia

Amal Elarabi; Zinab Saad; Fauzi Sagher

doi:10.4103/ijmbs.ijmbs_53_19

Ibnosina Journal of Medicine and Biomedical Sciences, Table of Contents

CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2019; 11(04): 188-191
DOI: 10.4103/ijmbs.ijmbs_53_19

Case Report

Hepatitis A-associated cholestasis and aplastic anemia

Amal Elarabi

¹Department of Paediatric Gastroenterology and Hepatology, Tripoli University Hospital, Tripoli

,

Zinab Saad

¹Department of Paediatric Gastroenterology and Hepatology, Tripoli University Hospital, Tripoli

²Department of Paediatric, Faculty of Medicine, University of Tripoli, Tripoli

,

Fauzi Sagher

¹Department of Paediatric Gastroenterology and Hepatology, Tripoli University Hospital, Tripoli

²Department of Paediatric, Faculty of Medicine, University of Tripoli, Tripoli

› Author Affiliations

Abstract

Hepatitis A virus (HAV) infection in children is typically an acute, self-limited illness associated with general, nonspecific symptoms. Prolonged cholestasis is a rare atypical form of HAV infection that is characterized by serum bilirubin levels higher than 10 mg/dl for more than 12 weeks. Aplastic anemia is another very rare complication of HAV. We report the case of an 11-year-old male with blood group O Rh positive who developed cholestasis followed by aplastic anemia postfulminant HAV infection. Liver function tests rapidly responded to a short course of steroid treatment. The patient had a sickle cell trait and a variant of ABCB11 gene. There was no history of traditional herbal treatment, but we noticed several cautery marks. Immunosuppressive medication was started for aplastic anemia, and he is listed for urgent bone marrow transplant. This is the first reported case of prolonged cholestasis followed by aplastic anemia complicating fulminant HAV infection in a Libyan adolescent.

Key-words:

Aplastic anemia - cholestasis - hepatitis A

Full Text

References

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