Coccoid Helicobacter pylori: An uncommon form of a common pathogen

Heidi Reinhard; Mary Jarad; Vanessa Ladd; Samir Kahwash

doi:10.4103/ijmbs.ijmbs_48_19

Ibnosina Journal of Medicine and Biomedical Sciences, Table of Contents

CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2019; 11(03): 120-123
DOI: 10.4103/ijmbs.ijmbs_48_19

Pathology Corner

Coccoid Helicobacter pylori: An uncommon form of a common pathogen

Authors

Heidi Reinhard

¹Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohia
Mary Jarad

²Department of Biological Sciences, The Ohio State University, Columbus, Ohia
Vanessa Ladd

¹Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohia
Samir Kahwash

¹Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohia

Abstract

Microscopic recognition remains a major component of diagnosing specific infectious agents or, at the minimum, an important first step in initiating a workup to confirm a specific infectious etiology. However, organisms are known to adapt in response to treatment, not only by developing resistance mechanisms but also undergoing major morphologic changes in some cases. Such morphologic adaptation can make them drastically different and hence difficult to recognize or characterize by an unwary examiner. The purpose of this article is to highlight a rare and unusual form of Helicobacter pylori referred to as coccoid H. pylori.

Key-words:

Antibiotic altered organisms - coccoid Helicobacter - Helicobacter heilmannii - Helicobacter pylori

Full Text

References

References
1 Hua JS, Zheng PY, Bow H. Species differentiation and identification in the genus of Helicobacter. World J Gastroenterol 1999;5:7-9.
2 Yamaguchi H, Osaki T, Takahashi M, Taguchi H, Kamiya S. Colony formation by Helicobacter pylori after long-term incubation under anaerobic conditions. FEMS Microbiol Lett 1999;175:107-11.
3 Azevedo NF, Almeida C, Cerqueira L, Dias S, Keevil CW, Vieira MJ. Coccoid form of Helicobacter pylori as a morphological manifestation of cell adaptation to the environment. Appl Environ Microbiol 2007;73:3423-7.
4 Kusters JG, Gerrits MM, Van Strijp JA, Vandenbroucke-Grauls CM. Coccoid forms of Helicobacter pylori are the morphologic manifestation of cell death. Infect Immun 1997;65:3672-9.
5 Chan WY, Hui PK, Leung KM, Chow J, Kwok F, Ng CS. Coccoid forms of Helicobacter pylori in the human stomach. Am J Clin Pathol 1994;102:503-7.
6 Balakrishna JP, Filatov A. Coccoid forms of Helicobacter pylori causing active gastritis. Am J Clin Pathol 2013;140 Suppl 1:A101.
7 Reshetnyak VI, Reshetnyak TM. Significance of dormant forms of Helicobacter pylori in ulcerogenesis. World J Gastroenterol 2017;23:4867-78.
8 Bode G, Mauch F, Malfertheiner P. The coccoid forms of Helicobacter pylori. Criteria for their viability. Epidemiol Infect 1993;111:483-90.
9 Oliva MM, Lazenby AJ, Perman JA. Gastritis associated with Gastrospirillum hominis in children. Comparison with Helicobacter pylori and review of the literature. Mod Pathol 1993;6:513-5.
10 Gardner A. Morphological effects of penicillin on bacteria. Nature 1940;146:837.
11 Lorian V, Atkinson B. Abnormal forms of bacteria produced by antibiotics. Am J Clin Pathol 1975;64:678-88.
12 Healy DP, Gardner JC, Puthoff BK, Kagan RJ, Neely AN. Antibiotic-mediated bacterial filamentation: A potentially important laboratory phenomenon. Clin Microbiol Newsl 2007;3:22-4.
13 Almarzooqi S, Leber A, Kahwash S. Artifacts and organism mimickers in pathology: Case examples and review of literature. Adv Anat Pathol 2010;17:277-81.
14 Buckley K, Feldman A, Kahwash S. Filamentous rods in the cerebrospinal fluid of a child with ventriculoperitoneal shunt: “Separation anxiety” at the microscopic level! Ibnosina J Med Biomed Sci 2019;11:38-40.