ABSTRACT
Objective: The aim of this study was to assess the anxiety, depression, and serum cortisol level
in OSMF patients. Materials and Methods: This cross-sectional study was conducted in the Outpatient Department of Oral Medicine
and Radiology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad,
Uttar Pradesh, India. Age-and gender-matched 105 patients were divided into three
equal groups as follows: Group 1 – those with areca nut chewing habits and OSMF, Group
2 – those with areca nut chewing habits but no OSMF, and Group 3– those without areca
nut chewing habits and without OSMF. Anxiety and depression were assessed by the Hamilton
Anxiety Rating Scale and the Hamilton Depression Rating Scale, respectively. Serum
cortisol level was also measured simultaneously. Statistical Analysis: Paired t-test, Chi-square test, and analysis of variance were used. Results: Fifty (47.62%) patients were observed to be in the age group of 25–32 years. Ninety-six
(91.4%) patients were males and 9 (8.6%) were females. The mean serum cortisol level
was observed to be higher among patients with OSMF-C followed by those with OSMF-D.
Conclusion: We conclude that there is a significant association between OSMF, depression, and
serum cortisol level.
Key words:
Anxiety - depression - oral submucous fibrosis - serum cortisol