Schwannoma is a slow-growing, encapsulated benign tumor of the neuroectodermal origin
arising from the perineural Schwann cells. This study aims to elucidate the clinicoradiographical
and histopathological features of orofacial schwannomas through a case series of seven
cases. The patients' aged ranged from 13 to 45 years, with a male predilection in
the ratio of 5:2. One intraosseous case presented as a radiolucent lesion. All the
cases exhibited Antoni A and Antoni B type of microscopic patterns in varying amounts.
One case of ancient schwannoma showed degenerative features. The tumor cells showed
diffuse positive immunohistochemical reaction for S-100 protein. Our study suggests
that intraosseous schwannoma should be considered in the differential diagnosis of
the intraosseous jaw lesions. Histopathologically, it is important to recognize the
findings of ancient schwannoma and to avoid misdiagnosing it as a malignant lesion.
Key-words:
Ancient schwannoma - Antoni A and Antoni B areas - intraosseous schwannoma - S-100
protein - Verocay bodies
