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CC BY-NC-ND 4.0 · Libyan International Medical University Journal 2020; 05(02): 48-52
DOI: 10.4103/LIUJ.LIUJ_7_20
Original Article

Histopathologic changes in aborted placenta

A Ashour
Department of Pathology, Faculty of Medicine, University of Benghazi, Benghazi
,
Nabeia Gheryani
Department of Pathology, Faculty of Medicine, University of Benghazi, Benghazi
,
Tunis Meidan
1   Department of Family and Community Medicine, Faculty of Medicine, University of Benghazi, Benghazi, Libya
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Abstract

Introduction: Histopathological examination of the placenta with clinical implications helps to make the diagnosis and deduce the cause of abortion, fetal mortality, morbidity, and pregnancy complications. Aim: This study aims to determine the frequencies and types of abnormalities of the chorionic villi in the aborted placentae. Materials and Methods: All specimens of products of conception submitted to a private histopathology laboratory in Benghazi during the period (from January 01, 2016 to December 31, 2018) were formalin-fixed, paraffin-embedded, and histopathology reviewed using hematoxylin and eosin stain under light microscopy. The data collected and statistically analyzed using SPSS version 22. Results: The study involved 92 specimens, of which 86 were abnormal and the pathological changes include partial mole (48%), hydropic changes (19%), increased vascularity (chorioangiosis) (13%), fibrosis (10%), numerous Hofbauer macrophages (8%), and abnormal premature calcification (2%). The rest of the specimens (6.5%) were normal placentae. Most of the cases of partial mole (73%) were at the age group of ≥30 years, and cases of abnormal premature calcification were at the age of >40 years. Conclusion: The histopathologic examination is an important tool for diagnosing the placental abnormalities. Most cases of abortion have abnormalities in chorionic villi; the most common abnormality is the partial mole, followed by hydropic change, then increased vascularity (chorioangiosis), fibrosis, and numerous Hofbauer macrophages. Abnormal premature calcification is the least finding. Partial mole occurs at an older age group of ≥30 years.

Key-words:

Calcification - chorioangiosis - chorionic villi - fibrosis - Hofbauer macrophages - hydropic change - partial mole

Financial support and sponsorship

Nil.




Publication History

Received: 31 March 2020

Accepted: 08 July 2020

Article published online:
14 June 2022

© 2020. Libyan International Medical University. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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