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CC BY-NC-ND 4.0 · Libyan International Medical University Journal 2020; 05(02): 32-36
DOI: 10.4103/LIUJ.LIUJ_4_20
Original Article

Correlation between maternal copper deficiency and premature rupture of membranes: A case–Control study

Hamdi Nawfal
Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
,
Ahmad Alhamid
Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
,
Abd Al-Hamid Abd Al-Jawad
Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
,
Abdurrahman Waez
Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
,
Razan Hallak
Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
,
Sherine Shammou
Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
,
Somayya Tabsho
Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
,
Muhammad Mazketly
Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
,
Muhammad Saadi
Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
,
Amir Sakur
1   Analytical and Food Chemistry Department, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
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Abstract

Background: The association between maternal serum copper levels and premature rupture of membranes (PROM) is debated. Aims: This study aims to study the relationship between maternal serum copper levels and the incidence of PROM and to determine risk factors of PROM in Aleppo University Hospital of Obstetrics and Gynecology. Settings and Design: Sixty pregnant women were subjected for this study. Materials and Methods: Pregnant women were subjected for analyzing serum copper concentrations. Maternal serum copper levels were measured by atomic absorption spectroscope. Statistical Analysis: By SPSS (version 22.0). Results: A significant correlation was found between maternal serum copper levels and the incidence of PROM. The relationship presents when copper level is considered as a categorical variable, as mothers with copper deficiency were significantly more vulnerable for PROM (Odds ratios = 0.15, confidence intervals: 0.04–0.61, P = 0.002). Furthermore, the relationship presents when copper level is considered as a numerical variable, as mothers with lower serum copper levels were at significantly higher risk to develop PROM. Difference in means between the two groups was 40.87 μg/dL with CI (14.98–66.75) μg/dL (P = 0.003). Conclusion: Within its limitations, this study suggests a significant relationship between maternal serum copper levels and PROM.

Key-words:

Case control - copper - premature rupture of membranes - Syria

Financial support and sponsorship

Nil.




Publication History

Received: 10 March 2020

Accepted: 08 July 2020

Article published online:
14 June 2022

© 2020. Libyan International Medical University. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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