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DOI: 10.4103/LIUJ.LIUJ_4_20
Correlation between maternal copper deficiency and premature rupture of membranes: A case–Control study

Abstract
Background: The association between maternal serum copper levels and premature rupture of membranes (PROM) is debated. Aims: This study aims to study the relationship between maternal serum copper levels and the incidence of PROM and to determine risk factors of PROM in Aleppo University Hospital of Obstetrics and Gynecology. Settings and Design: Sixty pregnant women were subjected for this study. Materials and Methods: Pregnant women were subjected for analyzing serum copper concentrations. Maternal serum copper levels were measured by atomic absorption spectroscope. Statistical Analysis: By SPSS (version 22.0). Results: A significant correlation was found between maternal serum copper levels and the incidence of PROM. The relationship presents when copper level is considered as a categorical variable, as mothers with copper deficiency were significantly more vulnerable for PROM (Odds ratios = 0.15, confidence intervals: 0.04–0.61, P = 0.002). Furthermore, the relationship presents when copper level is considered as a numerical variable, as mothers with lower serum copper levels were at significantly higher risk to develop PROM. Difference in means between the two groups was 40.87 μg/dL with CI (14.98–66.75) μg/dL (P = 0.003). Conclusion: Within its limitations, this study suggests a significant relationship between maternal serum copper levels and PROM.
Financial support and sponsorship
Nil.
Publikationsverlauf
Eingereicht: 10. März 2020
Angenommen: 08. Juli 2020
Artikel online veröffentlicht:
14. Juni 2022
© 2020. Libyan International Medical University. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Mistry HD, Williams PJ. The importance of antioxidant micronutrients in pregnancy. Oxid Med Cell Longev 2011;2011:841749.
- 2 Collins JF, Prohaska JR, Knutson MD. Metabolic crossroads of iron and copper. Nutr Rev 2010;68:133-47.
- 3 O'Dell BL. Roles for Iron and Copper in Connective Tissue Biosynthesis. Philos Trans R Soc Lond B Biol Sci 1981;294:91-104.
- 4 Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL. Sheffield JS. Williams Obstetrics. 24th ed. New York: McGraw-Hill Education; 2014.
- 5 Parry S, Strauss JF 3rd. Premature rupture of the fetal membranes. N Engl J Med 1998;338:663-70.
- 6 Hwang JE, de Bruyne M, Warr CG, Burke R. Copper overload and deficiency both adversely affect the central nervous system of Drosophila. Metallomics 2014;6:2223-9.
- 7 Song X, Li B, Li Z, Wang J, Zhang D. High serum copper level is associated with an increased risk of preeclampsia in Asians: A meta-analysis. Nutr Res 2017;39:14-24.
- 8 Zeyrek D, Soran M, Cakmak A, Kocyigit A, Iscan A. Serum copper and zinc levels in mothers and cord blood of their newborn infants with neural tube defects: A case-control study. Indian Pediatr 2009;46:675-80.
- 9 Abass RM, Hamdan HZ, Elhassan EM, Hamdan SZ, Ali NI, Adam I. Zinc and copper levels in low birth weight deliveries in Medani Hospital, Sudan. BMC Res Notes 2014;7:386.
- 10 Gautam B, Deb K, Banerjee M, Ali MS, Akhter S, Shahidullah SM, et al. Serum zinc and copper level in children with protein energy malnutrition. Mymensingh Med J 2008;17:S12-5.
- 11 Merenstein GB, Weisman LE. Premature rupture of the membranes: Neonatal consequences. Semin Perinatol 1996;20:375-80.
- 12 Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ER, et al. Obstetrics: Normal and Problem Pregnancies. Philadelphia, PA: Elsevier Health Sciences; 2016.
- 13 Rahmanian M, Jahed FS, Yousefi B, Ghorbani R. Maternal serum copper and zinc levels and premature rupture of the foetal membranes. J Pak Med Assoc 2014;64:770-4.
- 14 Artal R, Burgeson R, Fernandez FJ, Hobel CJ. Fetal and maternal copper levels in patients at term with and without premature rupture of membranes. Obstet Gynecol 1979;53:608-10.
- 15 Fu YH. Serum copper levels and pathologic changes in the fetal membranes in cases of premature rupture of the membranes. Zhonghua Fu Chan Ke Za Zhi 1989;24:276-8, 317.
- 16 Kiilholma P, Grönroos M, Erkkola R, Pakarinen P, Näntö V. The role of calcium, copper, iron and zinc in preterm delivery and premature rupture of fetal membranes. Gynecol Obstet Invest 1984;17:194-201.
- 17 Seddighi Looye E, Moghaddam Banaem L, Afshar A. Relationships between maternal copper and iron serum levels with pregnancy outcomes and relationship between their maternal and cord levels. Hayat 2012;17:16-25.
- 18 Kucukaydin Z, Kurdoglu M, Kurdoglu Z, Demir H, Yoruk IH. Selected maternal, fetal and placental trace element and heavy metal and maternal vitamin levels in preterm deliveries with or without preterm premature rupture of membranes. J Obstet Gynaecol Res 2018;44:880-9.
- 19 Bakhshandeh Nosrat S, Ghaemi EA, Ahmadi A, Behnampour N, Marjani A, Mansourian AR. Maternal serum copper concentration in premature rupture of membrane: A case-control study. J Biol Sci 2014;14:73-6.
- 20 Shen PJ, Gong B, Xu FY, Luo Y. Four trace elements in pregnant women and their relationships with adverse pregnancy outcomes. Eur Rev Med Pharmacol Sci 2015;19:4690-7.