A case of myelodysplastic syndrome with t(10;18)(q26;q21)

Yusuke Ohba; Minami Yamada-Fujiwara; Tadanori Minagawa; Suguru Watanabe; Yoko Okitsu; Yoshihiko Izumi; Junichi Kameoka; Shinichiro Takahashi

doi:10.4103/JLP.JLP_61_19

Journal of Laboratory Physicians, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · J Lab Physicians 2019; 11(04): 382-384
DOI: 10.4103/JLP.JLP_61_19

Case Report

A case of myelodysplastic syndrome with t(10;18)(q26;q21)

Yusuke Ohba

Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

,

Minami Yamada-Fujiwara

Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

Division of Blood Transfusion and Cell Therapy, Tohoku University Hospital, Sendai, Japan

,

Tadanori Minagawa

Department of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

,

Suguru Watanabe

Department of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

,

Yoko Okitsu

Department of Blood Transfusion, Tohoku Medical and Pharmaceutical University, Sendai, Japan

Division of Laboratory Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan

,

Yoshihiko Izumi

Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

,

Junichi Kameoka

Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

,

Shinichiro Takahashi

Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

Division of Laboratory Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan

› Institutsangaben

Abstract

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Abstract

An 82-year-old male was admitted. Pancytopenia, a slightly low white blood cell count (3400/μL), and low levels of red blood cells (2.65 × 10⁶/μL), hemoglobin (10.4 g/dL), and platelets (118,000/μL) were observed. Bone marrow aspiration was performed, revealing hypocellular bone marrow and normal blast levels (0.6%) with no dysplasia. G-banding chromosome analysis revealed the karyotype 45,X,-Y[3]/45, idem, t(10;18)(q26;q21)[13]/46,XY[4]. The patient was diagnosed with myelodysplastic syndrome, unclassified (MDS–U). This is the first case report demonstrating a patient with the chromosomal translocation, t(14;18)(q32;q21), which is extremely rare. This chromosomal aberration was critical for the diagnosis of MDS in this patient.

Key words

Chromosome banding - myelodysplastic syndromes - t(10;18)(q26;q21)

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Referenzen

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