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CC BY-NC-ND 4.0 · J Lab Physicians 2019; 11(04): 382-384
DOI: 10.4103/JLP.JLP_61_19
Case Report

A case of myelodysplastic syndrome with t(10;18)(q26;q21)

Yusuke Ohba
Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
,
Minami Yamada-Fujiwara
Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
Division of Blood Transfusion and Cell Therapy, Tohoku University Hospital, Sendai, Japan
,
Tadanori Minagawa
Department of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
,
Suguru Watanabe
Department of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
,
Yoko Okitsu
Department of Blood Transfusion, Tohoku Medical and Pharmaceutical University, Sendai, Japan
Division of Laboratory Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
,
Yoshihiko Izumi
Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
,
Junichi Kameoka
Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
,
Shinichiro Takahashi
Department of Clinical Laboratory, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan
Division of Laboratory Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
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Abstract

An 82-year-old male was admitted. Pancytopenia, a slightly low white blood cell count (3400/μL), and low levels of red blood cells (2.65 × 106/μL), hemoglobin (10.4 g/dL), and platelets (118,000/μL) were observed. Bone marrow aspiration was performed, revealing hypocellular bone marrow and normal blast levels (0.6%) with no dysplasia. G-banding chromosome analysis revealed the karyotype 45,X,-Y[3]/45, idem, t(10;18)(q26;q21)[13]/46,XY[4]. The patient was diagnosed with myelodysplastic syndrome, unclassified (MDS–U). This is the first case report demonstrating a patient with the chromosomal translocation, t(14;18)(q32;q21), which is extremely rare. This chromosomal aberration was critical for the diagnosis of MDS in this patient.

Key words

Chromosome banding - myelodysplastic syndromes - t(10;18)(q26;q21)


Publikationsverlauf

Eingereicht: 08. April 2019

Angenommen: 22. November 2019

Artikel online veröffentlicht:
07. April 2020

© 2019.

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