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CC BY-NC-ND 4.0 · J Lab Physicians 2017; 9(03): 149-155
DOI: 10.4103/JLP.JLP_44_16
Original Article

A clinico-pathological study of lupus nephritis based on the International Society of Nephrology-Renal Pathology Society 2003 classification system

Suchitha Satish
Department of Pathology, JSS Medical College, JSS University, Mysore, Karnataka, India
,
Pallavi Deka
Department of Pathology, JSS Medical College, JSS University, Mysore, Karnataka, India
,
Manjunath Sanjeev Shetty
Department of Nephrology, JSS Medical College, JSS University, Mysore, Karnataka, India
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Financial support and sponsorship Nil.
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Abstract

INTRODUCTION: Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE). Renal involvement is a major determinant of the prognosis of SLE. The histological classification of LN is a key factor in determining the renal survival of patients with LN. Prompt recognition and treatment of renal disease are important, as early response to therapy is correlated with better outcome and renal biopsy plays an important role in achieving this.

OBJECTIVES: The objective of this study was to correlate the clinical and laboratory findings with histopathological classes of LN as per the 2003 International Society of Nephrology-Renal Pathology Society (ISN/RPS) classification system.

PATIENTS AND METHODS: Fifty-six patients with SLE, undergoing a renal biopsy for renal dysfunction were studied. The comparison of data from multiple groups was made by Pearson’s Chi-square test and between two groups by independent samples t-test. The values of P < 0.05 were considered statistically significant.

RESULTS: Of the 56 cases studied, 51 (91.1%) were females. The most common presenting symptoms were edema, arthralgia, and hypertension. Class IV (55.4%) was the most common class. Thirty-nine (69.6%) cases showed full house immunostaining. Hypertension, hematuria, proteinuria, and tu bulo-interstitial disease showed a significant correlation (P < 0.05) with ISN/RPS classification, 2003.

CONCLUSION: Assessment and management of patients with suspected LN are greatly facilitated through information obtained by renal biopsy. Since renal morphology may predict long-term prognosis, and no clinical or laboratory feature uniformly predicts prognosis, it is important to study the constellation of features in LN for better patient management.

Key words

International Society of Nephrology-Renal Pathology Society classification - lupus nephritis - renal biopsy - systemic lupus erythematosus


Publication History

Received: 23 April 2016

Accepted: 23 January 2017

Article published online:
19 February 2020

© 2017.

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

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