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CC BY-NC-ND 4.0 · J Lab Physicians 2018; 10(02): 185-188
DOI: 10.4103/JLP.JLP_100_17
Original Article

Leukocyte count: A reliable marker for the severity of organophosphate intoxication?

Sunil Kumar
Department of Medicine, Jawaharlal Nehru Medical College, DMIMSU, Wardha, Maharashtra, India
,
Sachin Agrawal
Department of Medicine, Jawaharlal Nehru Medical College, DMIMSU, Wardha, Maharashtra, India
,
Nitin Raisinghani
Department of Medicine, Jawaharlal Nehru Medical College, DMIMSU, Wardha, Maharashtra, India
,
Shameem Khan
Department of Medicine, Jawaharlal Nehru Medical College, DMIMSU, Wardha, Maharashtra, India
› Author Affiliations Financial support and sponsorship: Nil
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ABSTRACT

INTRODUCTION: Organophosphorus poisoning (OPP) is a major public health problem in developing countries like India. Leukocyte count is a simple and inexpensive test, and elevated count is associated with acute inflammation and increased oxidative stress-like OPP. This study was done to correlate the severity of acute OPP with leukocyte count and also to assess the prognosis.

MATERIALS AND METHODS: A prospective, observational clinical study was done on 80 patients suspected of OPP of age >15 years admitted to emergency unit at a tertiary rural teaching health-care center of Central India. Serum cholinesterase level and leukocyte count were estimated at the time of admission in all patients and severity of OPP was assessed according to Peradeniya organophosphorus poisoning (POP) scale.

RESULTS: The mean age of the patients was 33.52 years (standard deviation [SD] 11.62) in males and 27.30 years (SD 7.33) in females. Among them, 57 (71.25%) were males and 23 (28.75%) were females. The severity of poisoning was directly correlated with serum cholinesterase level (P = 0.0001). Leukocyte count had a sensitivity of 60%, specificity of 76%, and negative predictive value of 85% if counts were more than 12,000 and 30% sensitivity, 95% specificity, and 80% negative predictive value if counts were more than 15,000 in predicting mortality in patients with OPP.

CONCLUSION: Leukocyte count levels on admission can be used a prognostic marker in patients with OP poisoning.

Keywords

Correlation - leukocyte count - organophosphorus - plasma cholinesterase - poisoning - severity


Publication History

Received: 23 July 2017

Accepted: 16 October 2017

Article published online:
19 February 2020

© 2018.

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

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