CC BY-NC-ND 4.0 · The Arab Journal of Interventional Radiology 2020; 4(02): 073-078
DOI: 10.4103/AJIR.AJIR_9_20
Original Article

Stimulan® Antibiotic Impregnated Beads for the Treatment of Diabetic Foot Infection

Hazel Ting Wai Chon
Department of Vascular Surgery, Northampton General Hospital, Northampton, United Kingdom
,
Maher Hamish
Department of Vascular Surgery, Northampton General Hospital, Northampton, United Kingdom
,
Piranavan Kirupananthan
Department of Vascular Surgery, Northampton General Hospital, Northampton, United Kingdom
,
Aimen Gmati
Department of Vascular Surgery, Northampton General Hospital, Northampton, United Kingdom
,
Hiba Abdalla
Department of Vascular Surgery, Northampton General Hospital, Northampton, United Kingdom
,
Robert Hicks
Department of Vascular Surgery, Northampton General Hospital, Northampton, United Kingdom
› Author Affiliations
Financial support and sponsorship Nil.

Context: Limited evidence has been found on the effectiveness of Stimulan® antibiotic beads for the treatment of diabetic foot ulcer. Aims: The aim of the study was to evaluate the safety and efficacy of Stimulan® antibiotic beads in treating diabetic foot infection and review the healing rate, infection recurrence rate, and the length of postoperative hospital stay. Settings and Design: It was a retrospective review of patients implanted with Stimulan® antibiotic beads at a district general hospital in England from 2017 to 2019. Subjects and Methods: Nineteen patients with Wagner Grade 3 and 4 ulcers were included, with a mean age of 62.3 years. Stimulan®, an antibiotic loaded absorbable calcium sulfate biocomposite, was used to treat persistent diabetic foot infection with chronic osteomyelitis. Staphylococcus aureus was the most common bacteria isolated. Exclusion criteria consisted of those with Wagner Grade 1 or 2 ulcers and infections that had clinically responded to long courses of systemic antibiotics treatment. Results: All patients underwent local wound debridement with the application of Stimulan® beads and received intravenous antibiotics for 48 h postoperatively. The average postoperative hospital stay was 2 days. After 1 month of follow-up, 16 wounds (84%) fully healed, two wounds (11%) had partially healed, and one wound (5%) showed no sign of healing. Two patients (11%) had shown recurrence of diabetic foot infection in a different foot after 24 months. Amputation rate was 0% over 24 months. Conclusions: This study recorded the clinical efficacy of Stimulan® antibiotic beads by demonstrating 0% amputation rate after two years and shortened hospital stay. With a low recurrence rate (16%), Stimulan® beads could be considered as one of the alternative treatments in managing diabetic foot infection.



Publication History

Received: 07 April 2020
Received: 18 May 2020

Accepted: 17 June 2020

Article published online:
26 March 2021

© 2020. The Arab Journal of Interventional Radiology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. https://creativecommons.org/licenses/by-nc-nd/4.0/.

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