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CC BY-NC-ND 4.0 · European Journal of General Dentistry 2013; 2(03): 195-198
DOI: 10.4103/2278-9626.115974
Review Article

Apoptosis in normal oral tissues and odontogenesis

Ruchita Bali
Department of Oral and Maxillofacial Pathology, Shree Bankey Bihari Dental College and Research Centre, Masuri, Ghaziabad, Uttar Pradesh, India
,
Akhilesh Chandra
1   Department of Oral and Maxillofacial Pathology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Renuka Verma
2   Department of Oral and Maxillofacial Pathology, Carrier Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India
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Abstract

Programmed cell death or apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development, and chemical-induced cell death. Inappropriate apoptosis (either too little or too much) is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders, and many types of cancers. The process of apoptosis is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. An understanding of its role in the pathophysiology of oral tissues is pertinent to the development of novel therapeutic approaches. The developing tooth passes through the various morphologic stages and apoptosis is observed selectively in certain locations. This review focuses on the current knowledge of apoptosis emphasizing its role in normal oral tissues and odontogenesis.

Keywords

Apoptosis - necrosis - odontogenesis


Publication History

Article published online:
01 November 2021

© 2013. European Journal of General Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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