CC BY-NC-ND 4.0 · European Journal of General Dentistry 2013; 2(01): 8-12
DOI: 10.4103/2278-9626.106794
Review Article

Esoteric communiqué amid microbes in an oral biofilm

Harpreet Singh Grover
Department of Periodontics and Oral Implantology, SGT Dental College, Hospital and Research Institute, Gurgaon, Haryana, India
Shailly Luthra
Department of Periodontics and Oral Implantology, SGT Dental College, Hospital and Research Institute, Gurgaon, Haryana, India
Shruti Maroo
Department of Periodontics and Oral Implantology, SGT Dental College, Hospital and Research Institute, Gurgaon, Haryana, India
› Author Affiliations


Dental biofilms are complex and multispecies ecosystems, and its formation requires coordinated chemical signaling between different micro-organisms present in the oral cavity. During the initial stages of its formation, planktonic bacterial cells directly attach to surfaces of the oral cavity or indirectly bind to other bacterial cells. This binding occurs through co-aggregation, which is critical for the temporary retention of bacteria on dental surfaces as well as bacterial colonization. It is during this colonization that the micro-organisms are able to interact with each other. In general, interspecies interactions involve communication, typically via quorum sensing, and metabolic cooperation or competition. Interactions among species within a biofilm can be antagonistic, such as competition over nutrients and growth inhibition, or synergistic. In this review, we discuss these important interactions among oral bacteria within the dental biofilm communities and novel therapies that could inhibit pathogenic micro-organisms and disrupt biofilm.

Publication History

Article published online:
01 November 2021

© 2013. European Journal of General Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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  • References

  • 1 Kuramitsu HK, He X, Lux R, Anderson MH, Shi W. Interspecies Interactions within Oral Microbial Communities. Microbiol Mol Biol Rev 2007;71:653-70.
  • 2 Kolenbrander PE, Andersen RN, Blehert D, Egland P, Foster JS, Robert J, et al. Communication among Oral Bacteria. Microbiol Mol Biol Rev 2002;6:486-505.
  • 3 Kolenbrander PE, Palmer RJ, Periasamy S, Jakubovics NS. Oral multispecies biofilm development and the key role of cell-cell distance. Nat Rev Microbiol 2010;7:471-80.
  • 4 Rickard AH, Gilbert P, High NJ, Kolenbrander PE, Handley PS. Bacterial coaggregation: An integral process in the development of multi-species biofilms. Trends Microbiol 2003;11:94-100.
  • 5 Bassler BL, Losick R. Bacterially speaking. Cell 2006;125:237-46.
  • 6 Fuqua C, Greenberg EP. Listening in on bacteria: Acyl-homoserine lactone signalling. Nat Rev Mol Cell Biol 2002;3:685-95.
  • 7 Miller MB, Bassler BL. Quorum sensing in bacteria. Annu Rev Microbiol 2001;55:165-99.
  • 8 Jakubovics NS. Talk of the town: Interspecies communication in oral biofilms. Mol Oral Microbiol 2010;25:4-14.
  • 9 Taga ME, Semmelhack JL, Bassler BL. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol Microbiol 2001;42:777-93.
  • 10 Huang R, Li M, Gregory RL. Bacterial interactions in dental biofilm. Virulence 2011;2:435-44.
  • 11 Bucci V, Nadell CD, Xavier JB. The evolution of bacteriocin production in bacterial biofilms. Am Nat 2011;178:E162-73.
  • 12 Morales DK, Hogan DA. Candida albicans Interactions with Bacteria in the Context of Human Health and Disease. PLoS Pathog 2010;6:e1000886.
  • 13 Chen F, Wang D. Novel technologies for the prevention and treatment of dental caries: A patent survey. Expert Opin Ther Pat 2010;20:681-94.
  • 14 Eckert R, He J, Yarbrough DK, Qi F, Anderson MH, Shi W. Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide. Antimicrob Agents Chemother 2006;50:3651-7.
  • 15 Sharma N, Khuller N. Periodontal Vaccine: A New Paradigm for Prevention of Periodontal Diseases. J Oral Health Comm Dent 2010;4:23-8.
  • 16 Scheie AA, Petersen FC. The biofilm concept: Consequences for future prophylaxis of oral diseases? Crit Rev Oral Biol Med 2001;15:4-12.
  • 17 Konopka K, Goslinski T. Photodynamic therapy in dentistry. J Dent Res 2007;86:694-707.
  • 18 Soukos NS, Chen PS, Morris JT, Ruggiero K, Abernethy AD, Som S, et al. Photodynamic therapy for endodontic disinfection. J Endod 2006;32:979-84.
  • 19 O′Neill JF, Hope CK, Wilson M. Oral bacteria in multi-species biofilms can be killed by red light in the presence of toluidine blue. Lasers Surg Med 2002;31:86-90.