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CC BY-NC-ND 4.0 · European Journal of General Dentistry 2012; 1(02): 109-112
DOI: 10.4103/2278-9626.103398
Case Report

Granular cell ameloblastoma: A diagnostic dilemma for histopathologist

Vijaykumar G. Biradar
Department of Oral and Maxillofacial Pathology, Maharashtra University of Health Sciences, MIDSR Dental College, Hospital and Research Centre, Latur, Maharashtra, India
,
Rahul G. Latturiya
Department of Oral and Maxillofacial Pathology, Maharashtra University of Health Sciences, MIDSR Dental College, Hospital and Research Centre, Latur, Maharashtra, India
,
Surekha V. Biradar
Department of Oral and Maxillofacial Pathology, Maharashtra University of Health Sciences, MIDSR Dental College, Hospital and Research Centre, Latur, Maharashtra, India
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Abstract

A rare case of granular cell ameloblastoma in the posterior mandible of a 45-year-old female has been studied both histologically and immunohistochemically. Histopathologically, hematoxylin and eosin and Periodic acid Schiff (PAS) prepared sections of granular cell ameloblastoma showed granular neoplastic cells residing within the tumor follicles. To characterize the granular cells in ameloblastoma, we examined the expression of low molecular weight cytokeratin and S-100 protein using immunohistochemistry. Granular cells exhibited positivity only with cytokeratin while S-100 protein was negative. This result allowed easy distinction of granular cell ameloblastomas from similar tumors exhibiting granular cell changes, and indicated that the granularity in ameloblastoma cells is consequent to lysosomal overload.

Keywords

Ameloblastoma - granular cells - rare


Publication History

Article published online:
01 November 2021

© 2012. European Journal of General Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Philipsen HP, Reichart PA. Classification of odontogenictumours; A historical review. J Oral Pathol Med 2006;35:525-9.
  • 2 Rajendran R. Cysts and Tumors of Odontogenic Origin. In: Rajendran R, Shivapathsundaram S, editors. Shafer′s Text book of Oral Pathology. 5 th ed. New Delhi: Elsevier; 2006. p. 386.
  • 3 Siar CH, Ng KH, Chia TY. Combined granular cell ameloblastoma and plexiform granular cell odontogenictumour. Singapore Dent J 1990;15:35-7.
  • 4 Dina R, Marchetti C, Vallania G, Corinaldesi G, Eusebi V. Granularcellameloblastoma. An immunocytochemical study. Pathol Res Pract 1996;192:541-6.
  • 5 Gupta S, Grewal H, Sah K. Granular cell ameloblastoma showing desmoplasia. Ann Saudi Med 2012;32:537-40.
  • 6 Reichart PA, Philipsen HP, Sonner S. Ameloblastoma: Biological profile of 3677 cases. Eur J Cancer B Oral Oncol 1995;31:86-99.
  • 7 Nasu M, Takagi M, Yamamoto H. Ultrastructural and histochemical studies of granular-cellameloblastoma. J Oral Pathol 1984;13:448-56.
  • 8 Kumamoto H, Ooya K. Immunohistochemical and ultrastructural investigation of apoptotic cell death in granularcellameloblastoma. J Oral Pathol Med 2001;30:245-50.
  • 9 Bansal A, Bhatnagar A, Saxena S. Metastasizing granular cell ameloblastoma. J Oral Maxillofac Pathol 2012;16:122-4.
  • 10 Cranin AN, Bennett J, Solomon M, Quarcoo S. Massive Granular cell ameloblastoma with metastasis: Report of a case. J Oral Maxillofac Surg 1987;45:800-4.