Pregnancy on tamoxifen: Case-report and review of literature

Bajpai Jyoti; Chauhan Bharat; Nachanker Ankita; Bal Munita; Gupta Sudeep

doi:10.4103/2278-330X.195347

South Asian Journal of Cancer, Table of Contents

CC BY-NC-ND 4.0 · South Asian J Cancer 2016; 05(04): 209-210
DOI: 10.4103/2278-330X.195347

Letter to the Editor

Pregnancy on tamoxifen: Case-report and review of literature

Bajpai Jyoti

Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra

,

Chauhan Bharat

Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra

,

Nachanker Ankita

Department of Radiotherapy, Tata Memorial Centre, Mumbai, Maharashtra

,

Bal Munita

Department of Surgical Pathology, Tata Memorial Centre, Mumbai, Maharashtra

,

Gupta Sudeep

Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra

› Author Affiliations

References
1 Iguchi T, Hirokawa M, Takasugi N. Occurrence of genital tract abnormalities and bladder hernia in female mice exposed neonatally to tamoxifen. Toxicology 1986;42:1-11.
2 Tewari K, Bonebrake RG, Asrat T, Shanberg AM. Ambiguous genitalia in infant exposed to tamoxifen in utero. Lancet 1997;350:183.
3 Oksüzoglu B, Güler N. An infertile patient with breast cancer who delivered a healthy child under adjuvant tamoxifen therapy. Eur J Obstet Gynecol Reprod Biol 2002;104:79.
4 Isaacs RJ, Hunter W, Clark K. Tamoxifen as systemic treatment of advanced breast cancer during pregnancy - Case report and literature review. Gynecol Oncol 2001;80:405-8.
5 Halakivi-Clarke L, Cho E, Onojafe I, Liao DJ, Clarke R. Maternal exposure to tamoxifen during pregnancy increases carcinogen-induced mammary tumorigenesis among female rat offspring. Clin Cancer Res 2000;6:305-8.
6 Pugh DM, Sumano HS. The anti-implantation action of tamoxifen in mice. Arch Toxicol Suppl 1982;5:209-13.
7 Lim YC, Li L, Desta Z, Zhao Q, Rae JM, Flockhart DA, et al. Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J Pharmacol Exp Ther 2006;318:503-12.
8 Kedia-Mokashi N, Makawy AE, Saxena M, Balasinor NH. Chromosomal aberration in the post-implantation embryos sired by tamoxifen treated male rats. Mutat Res 2010;703:169-73.
9 Clark RM, Chua T. Breast cancer and pregnancy: The ultimate challenge. Clin Oncol (R Coll Radiol) 1989;1:11-8.
10 Poulet FM, Roessler ML, Vancutsem PM. Initial uterine alterations caused by developmental exposure to tamoxifen. Reprod Toxicol 1997;11:815-22.
11 Barthelmes L, Gateley CA. Tamoxifen and pregnancy. Breast 2004;13:446-51.
12 Cullins SL, Pridjian G, Sutherland CM. Goldenhar′s syndrome associated with tamoxifen given to the mother during gestation. JAMA 1994;271:1905-6.
13 Berger JC, Clericuzio CL. Pierre Robin sequence associated with first trimester fetal tamoxifen exposure. Am J Med Genet A 2008;146A: 2141-4.
14 Clark S. Prophylactic tamoxifen. Lancet 1993;342:168.
15 Patterson JS, Settatree RS, Adam HK, Kemp JV. Serum concentrations of tamoxifen and major metabolite during longterm nolvadex therapy, correlated with clinical response. Eur J Cancer Suppl 1980;1:89-92.
16 MacCallum J, Cummings J, Dixon JM, Miller WR. Concentrations of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours. Br J Cancer 2000;82:1629-35.
17 Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 6 ^th ed. Philadelphia: Williams and Wilkins; 2002. p. 1307-13.