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CC BY-NC-ND 4.0 · South Asian J Cancer 2016; 05(04): 196-203
DOI: 10.4103/2278-330X.195345
LUNG CANCER : Original Article

Efficacy and toxicity profile of maintenance pemetrexed in patients with stage IV adenocarcinoma lung in Indian population

Goyal Pankaj
Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Rohini, New Delhi
,
Batra Ullas
Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Rohini, New Delhi
,
Dinesh Chandra Doval
Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Rohini, New Delhi
,
Jain Parveen
Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Rohini, New Delhi
,
Upadhyay Kumar Amitabh
Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Rohini, New Delhi
,
Prasanta Kumar Dash
Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Rohini, New Delhi
,
Jain Akhil
Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Rohini, New Delhi
,
Agarwal Mohit
Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Rohini, New Delhi
,
Bajaj Rajat
Department of Medical Oncology, Rajiv Gandhi Cancer Institute, Rohini, New Delhi
› Author Affiliations Financial support and sponsorship: Nil.
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Abstract

Context: Lung cancer has been the most common cancer in the world for several decades. Pemetrexed is recommended as an option for the maintenance treatment in metastatic adenocarcinoma lung, if disease has not progressed immediately following platinum-based chemotherapy. Aims: To study efficacy and toxicity profile of pemetrexed as a maintenance chemotherapeutic agent in patients with stage IV adenocarcinoma lung, not progressing after first line chemotherapy. Settings and Design: This was an observational, prospective. We enrolled patients with stage IV adenocarcinoma lung who has not progressed on first line chemotherapy, from September 2013 to August 2014 at a tertiary care cancer institute in North India. Materials and Methods: In all, 108 patients with stage IV adenocarcinoma lung were started on induction pemetrexed/platinum chemotherapy. 60 patients with no disease progression & ECOG PS 0-2 were started on Pemetrexed maintenance. Progression free survival (PFS) and toxicity profile were recorded. Results: The mean number of maintenance cycles was 8.3 (range 2-28). 13 (21.6%) patients took >10 maintenance cycles. Pemetrexed maintenance therapy resulted in progression free survival (PFS) of 5.4 months. PFS on pemetrexed was consistent for all patient subgroups, including induction response: complete/partial responders (n-31) and stable disease (n-29). 14 patients had grade III/IV adverse events with anemia being the most common in 3/60 patients (5%). 3 patients (5%) developed renal dysfunction out of which 1 was grade III. Conclusions: Pemetrexed continuation maintenance chemotherapy is active and well tolerated. Pemetrexed maintenance should be considered in patients with advanced adenocarcinoma lung patients who have not progressed on completion of induction chemotherapy.

Key words

Adenocacinoma lung - pemetrexed - pemetrexed maintenance


Publication History

Article published online:
28 December 2020

© 2016. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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