Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma
Verantwortlicher Herausgeber dieser Rubrik:
18. Januar 2017 (online)
Olfactory groove schwannomas (OGS) are rare anterior cranial fossa base tumors with only 41 cases reported in literature. Olfactory ensheathing cell schwannoma (OECS) has similar clinico-radiological features as OGS, but a different cell of origin. In recent years, there is growing interest in OECS as more cases are being reported.
The objective was to study the clinico-radiological features of OGS and define the histological differentiation from OECS.
Materials and Methods
We retrospectively analyzed clinical, radiological, surgical and histopathological picture of all cases of OGS managed in our institute. Immuno histochemical studies were performed in these tumors for differentiating from OECS. A comprehensive review of articles published until date describing the operative treatment was done.
All three cases had presented with seizures, two had anosmia and papilledema. Gross-total resection was achieved in all our patients. One patient expired in the postoperative period due to septicemia. Positive expression to newer immuno histochemical biomarker CD57 (Leu7), with negative staining to smooth muscle α-actin (SMA) was helpful in confirming the diagnosis of OGS and differentiating it from OECS in all our cases.
OECS, though rare has to be differentiated from OGS using immuno histochemistry. Gross-total resection of OGS with preservation of olfactory function is often possible and curative. Although these tumors are commonly treated with microsurgical skull base approaches, an endoscopic endonasal approach can be considered in some cases, with repair using mucoperiosteal pedicled flap to prevent cerebrospinal fluid leak.
- 1 Figueiredo EG, Soga Y, Amorim RL, Oliveira AM, Teixeira MJ. The puzzling olfactory groove schwannoma: A systematic review. Skull Base 2011; 21: 31-36
- 2 Li YP, Jiang S, Zhou PZ, Ni YB. Solitary olfactory schwannoma without olfactory dysfunction: A new case report and literature review. Neurol Sci 2012; 33: 137-142
- 3 Yasuda M, Higuchi O, Takano S, Matsumura A. Olfactory ensheathing cell tumor: A case report. J Neurooncol 2006; 76: 111-113
- 4 Darie I, Riffaud L, Sai’kali S, Brassier G, Hamlat A. Olfactory ensheathing cell tumour: Case report and literature review. J Neurooncol 2010; 100: 285-289
- 5 Yamaguchi T, Fujii H, Dziurzynski K, Delashaw JB, Watanabe E. Olfactory ensheathing cell tumor: Case report. Skull Base 2010; 20: 357-361
- 6 Lin SC, Chen MH, Lin CF, Ho DM. Olfactory ensheathing cell tumor with neurofibroma-like features: A case report and review of the literature. J Neurooncol 2010; 97: 117-122
- 7 Ippili K, Ratnam BG, Gowrishankar S, Ranjan A, Lath R. Olfactory ensheathing cell tumor. Neurol India 2009; 57: 76-78
- 8 Ogino-Nishimura E, Nakagawa T, Mikami Y, Ito J. Olfactory ensheathing cell tumor arising from the olfactory mucosa. Case Rep Med 2012; 2012: 426853
- 9 Al-Ghanem R, Ramos-Pleguezuelos FM, Pérez-Darosa SI, Galicia-Bulnes JM, Cabrerizo-Carvajal F, El-Rubaidi OA. Olfactory ensheathing cell tumour: Case report and literature review. Neurocirugia (Astur) 2013; 24: 130-134
- 10 Jahed A, Rowland JW, McDonald T, Boyd JG, Doucette R, Kawaja MD. Olfactory ensheathing cells express smooth muscle alpha-actin in vitro and in vivo . J Comp Neurol 2007; 503: 209-223
- 11 Sturm KW, Bonis G, Kosmaoglu V. On a neurinoma of the cribriform lamina. Zentralbl Neurochir 1968; 29: 217-222
- 12 Adachi K, Yoshida K, Miwa T, Ikeda E, Kawase T. Olfactory schwannoma. Acta Neurochir (Wien) 2007; 149: 605-610
- 13 Ahmad FU, Gupta A, Sharma MC, Shukla G, Mehta VS. The enigmatic origin of subfrontal schwannomas: Report of a case without hyposmia. Acta Neurochir (Wien) 2006; 148: 671-672
- 14 Nelson E, Rennels M. Innervation of intracranial arteries. Brain 1970; 93: 475-490
- 15 Thamburaj K, Radhakrishnan VV, Thomas B, Nair S, Menon G. Intratumoral microhemorrhages on T2*-weighted gradient-echo imaging helps differentiate vestibular schwannoma from meningioma. AJNR Am J Neuroradiol 2008; 29: 552-557
- 16 Santhosh K, Kesavadas C, Radhakrishnan VV, Thomas B, Kapilamoorthy TR, Gupta AK. Usefulness of T2*-weighted MR sequence for the diagnosis of subfrontal schwannoma. J Neuroradiol 2007; 34: 330-333
- 17 Leong AS, Kumarason C, Leong FJ. Manual of Diagnostic Cytology. 2003. 2nd ed Greenwich Medical Media Ltd; Cambridge: p 134
- 18 Dabbs D. Diagnostic Immunochemistry. 2010. 3rd ed, Ch. 11 Saunders; p 345-346
- 19 Johnson MD, Glick AD, Davis BW. Immunohistochemical evaluation of Leu-7, myelin basic-protein, S100-protein glial-fibrillary acidic-protein and LN3 immunoreactivity in nerve sheath tumors and sarcomas. Arch Pathol Lab Med 1988; 112: 155-160
- 20 Kanaan HA, Gardner PA, Yeaney G, Prevedello DM, Monaco 3rd EA, Murdoch G. et al Expanded endoscopic endonasal resection of an olfactory schwannoma. J Neurosurg Pediatr 2008; 2: 261-265
- 21 Harada T, Kawauchi M, Watanabe M, Kyoshima K, Kobayashi S. Subfrontal schwannoma - Case report. Neurol Med Chir (Tokyo) 1992; 32: 957-960
- 22 Mirone G, Natale M, Scuotto A, Rotondo M. Solitary olfactory groove schwannoma. J Clin Neurosci 2009; 16: 454-456
- 23 Vincent AJ, Taylor JM, Choi-Lundberg DL, West AK, Chuah MI. Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes. Glia 2005; 1 (51) 132-147