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Indian Journal of Neurosurgery 2014; 03(02): 086-092
DOI: 10.4103/2277-9167.138913
Original Article
Thieme Medical and Scientific Publishers Private Ltd.

Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma

Andi Sadayandi Ramesh
,
Jagath Lal Gangadharan
1   Departments of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
,
Anita Mahadevan
2   Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
,
Aravinda Hanumanthapura Ramalingaiah
3   Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
,
Bhagavatula Indira Devi
1   Departments of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
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Publikationsdatum:
18. Januar 2017 (online)

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Abstract

Background

Olfactory groove schwannomas (OGS) are rare anterior cranial fossa base tumors with only 41 cases reported in literature. Olfactory ensheathing cell schwannoma (OECS) has similar clinico-radiological features as OGS, but a different cell of origin. In recent years, there is growing interest in OECS as more cases are being reported.

Aims

The objective was to study the clinico-radiological features of OGS and define the histological differentiation from OECS.

Materials and Methods

We retrospectively analyzed clinical, radiological, surgical and histopathological picture of all cases of OGS managed in our institute. Immuno histochemical studies were performed in these tumors for differentiating from OECS. A comprehensive review of articles published until date describing the operative treatment was done.

Results

All three cases had presented with seizures, two had anosmia and papilledema. Gross-total resection was achieved in all our patients. One patient expired in the postoperative period due to septicemia. Positive expression to newer immuno histochemical biomarker CD57 (Leu7), with negative staining to smooth muscle α-actin (SMA) was helpful in confirming the diagnosis of OGS and differentiating it from OECS in all our cases.

Conclusions

OECS, though rare has to be differentiated from OGS using immuno histochemistry. Gross-total resection of OGS with preservation of olfactory function is often possible and curative. Although these tumors are commonly treated with microsurgical skull base approaches, an endoscopic endonasal approach can be considered in some cases, with repair using mucoperiosteal pedicled flap to prevent cerebrospinal fluid leak.

Key words

Leu7 (CD57) - olfactory ensheathing cell schwannoma - olfactory groove schwannoma - olfactory tract - smooth muscle α-actin
 

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