Cerebellar pleomorphic xanthoastrocytoma

Abstract

Pleomorphic xanthoastrocytoma (PXA) is a relatively rare neoplasm predominantly occurring in the supratentorial compartment. Among the unusual locations, cerebellum is the most common with few cases reported in the spinal cord and retina. The infratentorial PXA has a female preponderance, occurs in the fourth decade of life and is composite in 2/3^rd of the cases as compared to the supratentorial lesions. Gross total surgical excision is the goal, but is difficult due to the infiltration of the lesion into brainstem/upper cervical cord. Adjuvant radio/chemotherapy for recurrent/progressive/malignant forms have been, reported, but with variable results. This case is of a 25-year-old man who had a cerebellar PXA extending into the upper cervical cord that was sub-totally excised.

Key words

Cerebellum - pleomorphic xanthoastrocytoma - spinal cord

• References

• 1 Hamlat A, Le Strat A, Guegan Y, Ben-Hassel M, Saikali S. Cerebellar pleomorphic xanthoastrocytoma: Case report and literature review. Surg Neurol 2007; 68: 89-94
• 2 Yeaney GA, O’Connor SM, Jankowitz BT, Hamilton RL. A 16-year-old male with a cerebellar mass. Brain Pathol 2009; 19: 167-170
• 3 Gardiman MP, Fassan M, Orvieto E, laria L, Calderone M, Mardari R. et al A 14-year-old girl with multiple tumors. Brain Pathol 2012; 22: 865-868
• 4 Mano Y, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T. A case report of cerebellar pleomorphic xanthoastrocytoma. No Shinkei Geka 2009; 37: 586-590
• 5 Nakamura M, Chiba K, Matsumoto M, Ikeda E, Toyama Y. Pleomorphic xanthoastrocytoma of the spinal cord. Case report. J Neurosurg Spine 2006; 5: 72-75
• 6 Zarate JO, Sampaolesi R. Pleomorphic xanthoastrocytoma of the retina. Am J Surg Pathol 1999; 23: 79-81
• 7 Taraszewska A, Matyja E. Immunohistochemical studies in diagnosis of the uncommon cases of tumours of the central nervous system. Folia Histochem Cytobiol 2002; 40: 207-208
• 8 Passone E, Pizzolitto S, D’Agostini S, Skrap M, Gardiman MP, Nocerino A. et al Non-anaplastic pleomorphic xanthoastrocytoma with neuroradiological evidences of leptomeningeal dissemination. Childs Nerv Syst 2006; 22: 614-618
• 9 Sharma A, Nand Sharma D, Kumar Julka P, Kishor Rath G. Pleomorphic xanthoastrocytoma-A clinico-pathological review. Neurol Neurochir Pol 2011; 45: 379-386