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CC BY-NC-ND 4.0 · Avicenna J Med 2014; 04(02): 34-36
DOI: 10.4103/2231-0770.130343
CASE REPORT

Simultaneous hepatosplenic T-cell lymphoma and myelofibrosis

Ali M Gabali
Department of Pathology, Wayne State University, Detroit, MI 48201, USA
,
Tarek Jazaerly
Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA
,
Chung-Che Jeff Chang
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, The Methodist Hospital Research Institute, Houston, TX, USA
,
Ronald Cleveland
Department of Pathology, Case Western Reserve University, Metro Health Medical Center, Cleveland, Ohio
,
Lawrence Kass
Department of Pathology, Case Western Reserve University, Metro Health Medical Center, Cleveland, Ohio
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Abstract

Hepatosplenic T-cell lymphoma (HSTL) is a rare T-cell neoplasm of the lymphoid system. This type of lymphoma is characterized by sinusoidal infiltration of spleen, liver, bone marrow and lymph nodes by neoplastic lymphocytes. Here, we discuss a patient who had a left axillary lymph node biopsy with characteristic histological and immunohistochemical features of HSTL. In addition, infiltrating neoplastic T-cells and simultaneous characteristic features of myelofibrosis (MF) were also present in the bone marrow biopsy specimen. In contrast to secondary MF, primary MF is a progressive disease and may significantly affect the prognosis of coexisting HSTL. There are few reports in the literature talking about mild bone marrow fibrosis in association with T cell lymphoma, however marked increase in bone marrow fibrosis and HSTL never being reported. This case is shedding light on HSTL and marked increase in bone marrow fibrosis.

Keywords

Bone marrow - CD3 - Jak2 - liver - T-cell


Publikationsverlauf

Artikel online veröffentlicht:
09. August 2021

© 2014. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Olsen RJ, Tang Z, Farkas DH, Bernard DW, Zu Y, Chang CC. Detection of the JAK2 (V617F) mutation in myeloproliferative disorders by melting curve analysis using the LightCycler system. Arch Pathol Lab Med 2006;130:997-1003.
  • 2 Franco V, Florena AM. Hepatosplenic T-cell lymphoma. Br J Haematol 2001;114:3.
  • 3 Weidmann E. Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. Leukemia 2000;14:991-7.
  • 4 Kumar S, Lawlor C, Jaffe ES. Hepatosplenic T-cell lymphoma of alphabeta lineage. Am J Surg Pathol 2001;25:970-1.
  • 5 Macon WR, Levy NB, Kurtin PJ, Salhany KE, Elkhalifa MY, Casey TT, et al. Hepatosplenic alphabeta T-cell lymphomas: A report of 14 cases and comparison with hepatosplenic gammadelta T-cell lymphomas. Am J Surg Pathol 2001;25:285-96.
  • 6 Belhadj K, Reyes F, Farcet JP, Tilly H, Bastard C, Angonin R, et al. Hepatosplenic gammadelta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: Report on a series of 21 patients. Blood 2003;102:4261-9.
  • 7 Ahmed A, Chang CC. Chronic idiopathic myelofibrosis: Clinicopathologic features, pathogenesis, and prognosis. Arch Pathol Lab Med 2006;130:1133-43.
  • 8 Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005;7:387-97.
  • 9 Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005;365:1054-61.
  • 10 Rao SA, Gottesman SR, Nguyen MC, Braverman AS. T cell lymphoma associated with myelofibrosis. Leuk Lymphoma 2003;44:715-8.