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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2010; 02(06): 269-277
DOI: 10.4103/1947-489X.211007
Article

Chemopreventive and antilipidperoxidative potential of thespesia populnea (L.) on experimental buccal pouch carcinogenesis

Autor*innen

  • Sasikumar Dhanarasu

    1   Department of Biochemistry, College of Medicine, University of Ha'il, Kingdom of Saudi Arabia

  • Awdah Al-hazimi

    2   Department of Medical Education, College of Medicine, University of Ha'il, Kingdom of Saudi Arabia

  • Prema Sethuraman

    3   Department of Siddha Medicine, Faculty of Science, Tamil University, Tamil Nadu, India

  • Mathi Selvam

    1   Department of Biochemistry, College of Medicine, University of Ha'il, Kingdom of Saudi Arabia
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The present study has investigated the chemopreventive potential and antilipidperoxidative effect of ethanolic extract of Thespesia populnea (L.)bark on 7,12-dimethylbenz[a] anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Oral squamous cell carcinoma had developed in Syrian golden hamsters by exposing the buccal mucosa to 0.5 % DMBA in liquid paraffin thrice a week for 14 weeks. The tumor incidence, tumor volume and tumor burden that occurred in the hamster buccal pouch were determined. Oral administration of ethanolic extract of T.populnea bark at a dose of 300 mg/kg b.wt to DMBA painted animals on alternate days of DMBA treated for 14 weeks significantly prevented the tumor incidence, tumor volume and tumor burden. Ethanolic extract of T.populnea bark showed potent antilipidperoxidative effect as well as enhanced the antioxidants status in DMBA painted animals. We thus conclude that ethanolic extract of T.populnea bark has potent chemopreventive efficacy and significant antilipidperoxidative effect in DMBA induced oral carcinogenesis. Further studies are needed to isolate and characterize the bioactive chemopreventive component from the bark of T.populnea.

Key-words:

Oral cancer - Thespesia populnea - Chemoprevention - Lipidperoxidation


Publikationsverlauf

Eingereicht: 28. Juni 2010

Angenommen: 01. Oktober 2010

Artikel online veröffentlicht:
23. Mai 2022

© 2010. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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