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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2011; 03(01): 15-20
DOI: 10.4103/1947-489X.210845
Article

Evaluation of the antidiarrheal activity of methanol leaf extract of Bombax Buonopozense in rats

G Akuodor
1   Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD)
,
I Muazzam
2   Department of Medicinal Plant and Traditional Medicine, National Institute for Pharmaceutical Research and Development (NIPRD), Idu, P.M.B. 21Garki, Abuja, Nigeria
,
M Usman-Idris
1   Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD)
,
U Megwas
3   Department of Pharmacology and Therapeutics, Abia State University, Uturu, Nigeria
,
J Akpan
4   Department of Pharmacology and Therapeutics, Faculty of Clinical Medicine, Ebonyi State University, Abakiliki, Nigeria
,
K Chilaka
5   Department of Pharmacology and Therapeutics, Nnamdi Azikiwe University, Awka, Nigeria
,
D Okoroafor
5   Department of Pharmacology and Therapeutics, Nnamdi Azikiwe University, Awka, Nigeria
,
U Osunkwo
1   Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD)
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Objectives: The methanolic extract of the leaves of Bombax buonopozense was screened for antidiarrheal effects. Materials and methods: The extract was evaluated for castor oil- induced diarrhoea and enteropooling as well as intestinal transit in rats. Results: Bombax buonopozense significantly (p<0.05) and dose-dependently reduced frequency of stooling in castor oil-induced diarrhoea, castor oil- induced enteropooling and intestinal motility in rats. The oral LD50 values obtained were greater than 5000 mg/kg in mice. Conclusion: These findings suggest that the methanolic extract of the leaves of B. buonopozense may contain some biologically active ingredients that are active for the treatment of diarrhoea in Nigerian herbal traditional medicine.



Publication History

Received: 25 January 2010

Accepted: 03 December 2010

Article published online:
23 May 2022

© 2011. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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