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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2016; 08(02): 28-51
DOI: 10.4103/1947-489X.210214
Review

Histopathologic identification and pattern recognition of common viral infections in the general pathology practice: An illustrated review

Flora Yazigi
1   Saint Louis University School of Medicine, ST. Louis, MO 63104, USA
,
Basil Kahwash
2   Department of Medicine, Indiana University, Indianapolis, IN, 46202, USA
,
Fahd Al Sufiani
3   Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus OH 43205, USA
,
Miriam Conces
3   Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus OH 43205, USA
,
Vinay Prasad
3   Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus OH 43205, USA
,
Samir Kahwash
3   Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus OH 43205, USA
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Pattern recognition and cytologic features remain essential diagnostic tools in pathology. Viral cytopathic effect may be the first clue to a diagnosis of a viral infection. This paper aims to provide a brief illustrated summary of the histopathologic changes caused by commonly encountered and rare viruses. The list of viruses discussed with characteristic viral inclusions or distinctive cytopathic effect includes cytomegalovirus, adenovirus, herpes virus (herpes simplex virus and varicella zoster virus), human papillomavirus, respiratory syncytial virus, parvovirus, poxvirus (molluscum contagiosum virus), and polyoma virus (JC virus and BK virus). Also reviewed are the characteristic histologic and cytopathic changes for Epstein-Barr virus (EBV), Paramyxoviruses (human parainfluenza virus and measles virus), human immunodeficiency virus (HIV), and hepatitis B virus.

Key-words:

Infections - Viral Inclusions - Viral Cytopathic Effects - Morphology.


Publication History

Received: 10 February 2016

Accepted: 10 February 2016

Article published online:
07 July 2022

© 2016. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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