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CC BY-NC-ND 4.0 · Asian J Neurosurg 2012; 7(04): 171-173
DOI: 10.4103/1793-5482.106648
ORIGINAL ARTICLE

Effects of a head-down tilt on cerebral blood flow in mice during bilateral common carotid artery occlusion

Kimihiro Nagatani
Department of Neurosurgery, National Defense Medical College, Saitama
,
Hiroshi Nawashiro
Department of Neurosurgery, National Defense Medical College, Saitama
,
Satoru Takeuchi
Department of Neurosurgery, National Defense Medical College, Saitama
,
Naoki Otani
Department of Neurosurgery, National Defense Medical College, Saitama
,
Kojiro Wada
Department of Neurosurgery, National Defense Medical College, Saitama
,
Katsuji Shima
Department of Neurosurgery, National Defense Medical College, Saitama
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Objectives: Data on the optimal head position for patients with acute ischemic stroke are unavailable. We evaluated the effects of mild head-down tilt (HDT) on cerebral blood flow (CBF) in mice during bilateral common carotid artery occlusion (BCCAO). Materials and Methods: We used mice with BCCAO (35 minutes) and divided these into 2 groups ( n=16): BCCAO at 0°-HDT and 5°-HDT. CBF was measured for both hemispheres with a non-invasive laser Doppler blood perfusion imager. Changes in CBF during BCCAO were examined in both groups. Results: A significantly greater increase in CBF in both hemispheres was observed in 5°-HDT mice than in 0°-HDT mice (126.1% (8.715)% vs. 102.1% (4.718)%; P=0.0294). Conclusion: HDT enhanced the increase in CBF in both hemispheres in the mouse BCCAO model. The potential mechanism underlying CBF increase enhanced by HDT during BCCAO warrants further investigation.

Key-words:

Bilateral common carotid artery occlusion - brain infarction - cerebral blood flow - head down - mouse


Publication History

Article published online:
27 September 2022

© 2012. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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