Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy

Ebru Olgun Erdemir; Meltem Karsiyaka Hendek; H. Gencay Keceli; Teoman Z. Apan

doi:10.4103/1305-7456.149644

European Journal of Dentistry, Table of Contents

CC BY-NC-ND 4.0 · Eur J Dent 2015; 09(01): 060-065
DOI: 10.4103/1305-7456.149644

Original Article

Dental Investigation Society

Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy

Ebru Olgun Erdemir

¹Department of Periodontology, Faculty of Dentistry, Kirikkale University, Merkez, Kirikkale, Turkiye

,

Meltem Karsiyaka Hendek

¹Department of Periodontology, Faculty of Dentistry, Kirikkale University, Merkez, Kirikkale, Turkiye

,

H. Gencay Keceli

²Department of Periodontology, Faculty of Dentistry, Hacettepe University, Sıhhiye, Ankara, Turkiye

,

Teoman Z. Apan

³Department of Medical Microbiology, Faculty of Medicine, Kirikkale University, Merkez, Kirikkale, Turkiye

› Author Affiliations

Abstract

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ABSTRACT

Objective: The aim of this study is to evaluate the influence of regenerative periodontal therapy on clinical parameters and interleukin-8 (IL-8), IL-17 and soluble intercellular adhesion molecule-1 (sICAM-1) levels in gingival crevicular fluid (GCF) of subjects with chronic periodontitis (CP). Materials and Methods: Fifteen patients received demineralized freeze-dried bone allograft (DFDBA) surgically to the site of infrabony defect. Clinical periodontal indices were recorded, and GCF samples were collected at baseline and at the 6^th and the 9^th month after the surgery. Results: Except plaque index, all clinical parameters improved following surgery (P < 0.05). The volume of GCF diminished from baseline to follow-up periods (P < 0.05). However, no effect was observed on the total amount of IL-8, IL-17 and sICAM-1 in GCF. Conclusion: DFDBA improved clinical outcome in CP subjects and was effective on decreasing the volume of GCF, but no effect was determined on IL-8, IL-17 and sICAM-1. Findings did not indicate a direct relationship between biochemical parameters and periodontal healing after demineralized freeze-dried bone grafting.

Key words:

Demineralized freeze-dried bone allograft - gingival crevicular fluid - interleukin-17 - interleukin-8 - soluble intercellular adhesion molecule-1

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References

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