CC BY-NC-ND 4.0 · Eur J Dent 2013; 07(03): 310-314
DOI: 10.4103/1305-7456.115415
Original Article
Dental Investigation Society

Effect of dietary boron on 5-fluorouracil induced oral mucositis in rats

Mutan Hamdi Aras
1   Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkiye
Ufuk Sezer
2   Department of Periodontology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkiye
Suna Erkilic
3   Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkiye
Tuncer Demir
4   Department of Physiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkiye
Seyda Nur Dagli
4   Department of Physiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkiye
› Author Affiliations
Further Information

Publication History

Publication Date:
26 September 2019 (online)


Objective: The aim of this study was to evaluate the effect of boron on 5-fluorouracil (5-FU)-induced oral mucositis in rats. Materials and Methods: Sixty-four male Wistar albino rats were injected with 5-FU on days 1 and 3. The right cheek pouch mucosa was scratched with the tip of an 18-G needle, dragged twice in a linear movement, on days 3 and 5. The animals were randomly divided into two groups of 32: boron group (BG) and control group (CG). Rats in the CG did not receive any treatment, whereas the others were fed boron (3 mg·kg -1·day -1 ) by gavage. The animals were sacrificed on day 3 (n = 8), 6 (n = 8), 9 (n = 8), and 12 (n = 8), and the cheek pouch was removed for histopathological analysis. Results: On day 3, both groups showed necrosis and active inflammation, but the inflammation was mild in CG and moderate in BG. On day 6, both BG and CG showed necrosis; in the CG, there was moderate inflammation, and in the BG, there was severe inflammation and granulation tissue around the necrotic area. On day 9, re-epithelization began in both groups, and there were no differences between groups. Re-epithelization was complete in both groups on day 12. Conclusion: We found no beneficial effect of boron in healing oral mucositis. Additional research is warranted to elucidate the pathogenic inflammatory mechanisms involved in mucositis and the prophylactic and therapeutic roles of antioxidants.


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