CC BY-NC-ND 4.0 · Journal of Digestive Endoscopy 2012; 03(S 05): 027-032
DOI: 10.4103/0976-5042.95027
Review Article
Society of Gastrointestinal Endoscopy of India

Endoscopic management of biliary injuries and leaks

T. S. Chandrasekar
Department of Medical Gastroenterology, MedIndia Institute of Medical Specialities, Chennai, MedIndia Hospitals, Coimbatore, India
,
Hameed Hussain
Department of Medical Gastroenterology, MedIndia Institute of Medical Specialities, Chennai, MedIndia Hospitals, Coimbatore, India
,
M. Murugesh
Department of Medical Gastroenterology, MedIndia Institute of Medical Specialities, Chennai, MedIndia Hospitals, Coimbatore, India
› Author Affiliations
Further Information

Publication History

Publication Date:
26 September 2019 (online)

Abstract

Bile duct injuries and subsequent leaks can occur following laparoscopic and open cholecystectomies and also during other hepatobiliary surgeries. Various patient related and technical factors are implicated in the causation of biliary injuries. Over a period of twenty five years managing such patients of biliary injuries our team has found a practical approach to assess the cause of biliary injuries based on the symptoms, clinical examination and imaging. Bismuth classification is helpful in most of the cases. Immediate referral to a centre experienced in the management of bile duct injury and timely intervention is associated with improved outcomes. Resuscitation, correcting dyselectrolytemia, aspiration of undrained biloma and antibiotics take the priority in the management. The goal is to restore the bile conduit, and to prevent short and longterm complications such as biliary fistula, intra-abdominal abscess, biliary stricture, recurrent cholangitis and secondary biliary cirrhosis. Endoscopic therapy by reducing the transpapillary pressure gradient helps in reducing the leak. Endoscopic therapy with biliary sphincterotomy alone or with additional placement of a biliary stent/nasobiliary drainage is advocated. In our tertiary care referral unit, we found endoscopic interventions are useful in situations where there is leak with associated CBD calculus or a foreign body, peripheral bile duct injury, cystic duct stump leak and partial bile duct injury with leak/narrowing of the lumen. Endotherapy is not useful in case of complete transection (total cut off) and complete stricture involving common hepatic or common bile ducts. In conclusion, endoscopic treatment can be considered a highly effective therapy and should be the first-line therapy in such patients. Though less successful, an endoscopic attempt is warranted in patients suffering from central bile duct leakages failing which surgical management is recommended.

 
  • References

  • 1 Adamsen S, Hansen OH, Funch-Jensen P, Schulze S, Stage JG, Wara P. Bile duct injury during laparoscopic cholecystectomy: A prospective nationwide series. J Am Coll Surg 1997;184:571-8.
  • 2 Flum DR, Cheadle A, Prela C, Dellinger EP, Chan L. Bile duct injury during cholecystectomy and survival in medicare beneficiaries. JAMA 2003;290:2168-73.
  • 3 Lai EC, Lau WY. Mirizzi syndrome: History, present and future development. ANZ J Surg 2006;76:251-7.
  • 4 Bismuth H. Postoperative strictures of the bile ducts. In: Blumgart LH, editor. The Biliary Tract V. New York, NY: Churchill-Livingstone; 1982. p. 209-18.
  • 5 Bismuth H, Majno PE. Biliary strictures: Classification based on the principles of surgical treatment. World J Surg 2001;25:1241-4.
  • 6 Strasberg SM, Hertl M, Soper NJ. An analysis of the problem of biliary injury during laparoscopic cholecystectomy. J Am Coll Surg 1995;180:101-25.
  • 7 Neuhaus P, Schmidt SC, Hintze RE, Adler A, Veltzke W, Raakow R, et al. Classification and treatment of bile duct injuries after laparoscopic cholecystectomy. Chirurg 2000;71:166-73.
  • 8 Llach J, Bordas JM, Elizalde JI, Enrico C, Ginès A, Pellisé M, et al. Sphincterotomy in the treatment of biliary leakage. Hepatogastroenterology 2002;49:1496-8.
  • 9 Kaffes AJ, Hourigan L, De Luca N, Byth K, Williams SJ, Bourke M. Impact of endoscopic intervention in 100 patients with suspected postcholecystectomy bile leak. Gastrointest Endosc 2005;61:269-75.
  • 10 Binmoeller KF, Katon RM, Shneidman R. Endoscopic management of postoperative biliary leaks: Review of 77 cases and report of two cases with biloma formation. Am J Gastroenterol 1991;86:227-31.
  • 11 Liguory C, Vitale GC, Lefebre JF, Bonnel D, Cornud F. Endoscopic treatment of postoperative biliary fistulae. Surgery 1991;110:779-83; discussion 783-4.
  • 12 Davids PH, Rauws EA, Tytgat GN, Huibregtse K. Postoperative bile leakage: Endoscopic management. Gut 1992;33:1118-22.
  • 13 Foutch PG, Harlan JR, Hoefer M. Endoscopic therapy for patients with a post-operative biliary leak. Gastrointest Endosc 1993;39:416-21.
  • 14 Woods MS, Shellito JL, Santoscoy GS, Hagan RC, Kilgore WR, Traverso LW, et al. Cystic duct leaks in laparoscopic cholecystectomy. Am J Surg 1994;168:560-3; discussion 563-5.
  • 15 Bourke MJ, Elfant AB, Alhalel R, Kortan P, Haber GB. Endoscopic management of post-operative bile leak (EMBL) in 85 patients [abstract]. Gastrointest Endosc 1995;41: AB 378.
  • 16 Bjorkman DJ, Carr-Locke DL, Lichtenstein DR, Ferrari AP, Slivka A, Van Dam J, et al. Postsurgical bile leaks: Endoscopic obliteration of the transpapillary pressure gradient is enough. Am J Gastroenterol 1995;90:2128-33.
  • 17 Prat F, Pelletier G, Ponchon T, Fritsch J, Meduri B, Boyer J, et al. What role can endoscopy play in the management of biliary complications after laparoscopic cholecystectomy? Endoscopy 1997;29:341-8.
  • 18 Ryan ME, Geenen JE, Lehman GA, Aliperti G, Freeman ML, Silverman WB, et al. Endoscopic intervention for biliary leaks after laparoscopic cholecystectomy: A multicenter review. Gastrointest Endosc 1998;47:261-6.
  • 19 Mergener K, Strobel JC, Suhocki P, Jowell PS, Enns RA, Branch MS, et al. The role of ERCP in the diagnosis and management of accessory bile duct leaks after cholecystectomy. Gastrointest Endosc 1999;50:527-31.
  • 20 De Palma GD, Iuliano GP, Puzziello A, Manfredini S, Masone S, Persico G. Biliary leaks after laparoscopic cholecystectomy. Results of the endoscopic treatment. Minerva Chir 2002;57:123-7.
  • 21 Marks JM, Ponsky JL, Shillingstad RB, Singh J. Biliary stenting is more effective than sphincterotomy in the resolution of biliary leaks. Surg Endosc 1998;12:327-30.
  • 22 Leung JW, Del Favero G, Cotton PB. Endoscopic biliary prostheses: A comparison of materials. Gastrointest Endosc 1985;31:93-5.
  • 23 Youngelman DF, Marks JM, Ponsky T, Ponsky JL. Comparison of bile duct pressures following sphincterotomy and endobiliary stenting in a canine model. Surg Endosc 1997;11:126-8.
  • 24 Chow S, Bosco JJ, Heiss FW, Shea JA, Qaseem T, Howell D. Successful treatment of post-cholecystectomy bile leaks using nasobiliary tube drainage and sphincterotomy. Am J Gastroenterol 1997;92:1839-43.
  • 25 Weber A, Feussner H, Winkelmann F, Siewert JR, Schmid RM, Prinz C. Long-term outcome of endoscopic therapy in patients with bile duct injury after cholecystectomy. J Gastroenterol Hepatol 2009; 24:762-9.
  • 26 Feliu Palá X, Encinas Méndez X, Poveda Gómez S, Martí Sintes G. Topical nitroglycerin: An alternative in the conservative treatment of biliary fistula. Rev Esp Enferm Dig 1996;88:877-9.
  • 27 Brodsky JA, Marks JM, Malm JA, Bower A, Ponsky JL. Sphincter of Oddi injection with botulinum toxin is as effective as endobiliary stent in resolving cystic duct leaks in a canine model. Gastrointest Endosc 2002;56:849-51.