CC BY-NC-ND 4.0 · J Lab Physicians 2011; 3(02): 069-074
DOI: 10.4103/0974-2727.86836
Review Article

Mycobacterium avium Subspecies Paratuberculosis and Crohn’s Regional Ileitis: How Strong is Association?

Sarman Singh
Department of Laboratory Medicine, Division of Clinical Microbiology, All India Institute of Medical Sciences, New Delhi, India
,
Krishnamoorthy Gopinath
MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa
› Institutsangaben
Source of Support: Nil

ABSTRACT

Mycobacterium avium subsp. paratuberculosis (MAP) is a well-established etiological agent of Johne’s disease in animals. In humans, similar clinical condition, first described by Crohn as regional ileitis in 1932, now known as Crohn’s diseases (CD), has also been associated with this mycobacterial species. However, there are two schools of thoughts, one favoring MAP as its etiological agent while the second considers it as an immune-inflammatory condition triggered by an external factor. Onset of CD requires a series of events including predisposition of certain inherited genetic traits, associated environmental stimuli, and immune-inflammatory response. A combination of these factors probably leads to this disease. Recently, some human genes have also been identified which regulate ability to respond appropriately to the external factors. Added to these factors are concerns about the selection of clinical specimens and poor adherence to laboratory quality controls. The literature is full of contradictory findings, but there a lack of uniformity in the materials and methods used by many of these researchers. In this review, we provide our perspective under above circumstances and give our point of view which may open a platform for debate regarding the MAP as the etiological agent of human CD.



Publikationsverlauf

Artikel online veröffentlicht:
09. Mai 2020

© 2011.

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  • REFERENCES

  • 1 Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis; a pathologic and clinical entity. JAMA 1932;99:1323-9.
  • 2 Hamilton SR, Morson BC. Crohn′s disease. Part 1: Pathology. In: Haubrich WS, Schaffner F, Berk JE, Bockus HL, editors. Bockus gastroenterology. Vol. 2. Philadelphia: W.B. Saunders; 1995. p. 1398-409.
  • 3 Buergelt CD, Duncan JR. Age and milk production data of cattle culled from a dairy herd with paratuberculosis. J Am Vet Med Assoc 1978;173:478-80.
  • 4 Benedictus G, Dijkhuizen AA, Stelwagen J. Economic losses due to paratuberculosis in dairy cattle. Vet Rec 1987;121:142-6.
  • 5 Clarke CJ. The pathology and pathogenesis of paratuberculosis in ruminants and other species. J Comp Pathol 1997;116:217-61.
  • 6 Dalziel TK. Chronic intestinal enteritis. Br Med J 1913;21068-70.
  • 7 Chiodini RJ, Van Kruiningen HJ, Merkal RS. Ruminant paratuberculosis Johne′s disease: The current status and future prospects. Cornell Vet 1984;74:218-62.
  • 8 Cocito C, Gilot P, Coene M, de Kesel M, Poupart P, Vannuffel P. Paratuberculosis. Clin Microbiol Rev 1994;7:328-45.
  • 9 Cellier C, De Beenhouwer H, Berger A, Penna C, Carbonnel F, Parc R, et al. Mycobacterium paratuberculosis and Mycobacterium avium subsp. silvaticum DNA cannot be detected by PCR in Crohn′s disease tissue. Gastroenterol Clin Biol 1998;22:675-8.
  • 10 Chiba M, Fukushima T, Horie Y, Iizuka M, Masamune O. No Mycobacterium paratuberculosis detected in intestinal tissue, including Peyer′s patches and lymph follicles, of Crohn′s disease. J Gastroenterol 1998;33:482-7.
  • 11 Clarkston WK, Presti ME, Petersen PF, Zachary PE Jr, Fan WX, Leonardi CL, et al. Role of Mycobacterium paratuberculosis in Crohn′s disease: A prospective, controlled study using polymerase chain reaction. Dis Colon Rectum 1998;41:195-9.
  • 12 Sung N, Collins MT. Variation in resistance of Mycobacterium paratuberculosis to acid environments as a function of culture medium. Appl Environ Microbiol 2003;69:6833-40.
  • 13 Ellingson JLE, Cheville JC, Brees D, Miller JM, Cheville NF. Absence of Mycobacterium avium subspecies paratuberculosis components from Crohn′s disease intestinal biopsy tissues. Clin Med Res 2003;1:217-26.
  • 14 Feller M, Huwiler K, Stephan R, Altpeter E, Shang A, Furrer H, et al. Mycobacterium avium subspecies paratuberculosis and Crohn′s disease: A systematic review and meta-analysis. Lancet Infect Dis 2007;7:607-13.
  • 15 Naser SA, Ghobrial G, Romero C, Valentine JF. Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn′s disease. Lancet 2004;364:1039-44.
  • 16 Sechi LA, Scanu AM, Molicotti P, Cannas S, Mura M, Dettori G, et al. Detection and isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn′s disease in Sardinia. Am J Gastroenterol 2005;100:1529-36.
  • 17 Clarke CJ, Patterson IA, Armstrong KE, Low JC. Comparison of the absorbed ELISA and agar gel immunodiffusion test with clinicopathological findings in ovine clinical paratuberculosis. Vet Rec 1996;139:618-21.
  • 18 Sanderson JD, Moss MT, Tizard ML, Hermon-Taylor J. Mycobacterium paratuberculosis DNA in Crohn′s disease tissue. Gut 1992;33:890-96.
  • 19 Bull TJ, McMinn EJ, Sidi-Boumedine K, Skull A, Durkin D, Neild P, et al. Detection and verification of Mycobacterium avium subsp. paratuberculosis in fresh ileocolonic mucosal biopsy specimens from individuals with and without Crohn′s disease. J Clin Microbiol 2003;41:2915-23.
  • 20 Scanu AM, Bull TJ, Cannas S, Sanderson JD, Sechi LA, Dettori G, et al. Mycobacterium avium subspecies paratuberculosis infection in cases of irritable bowel syndrome and comparison with Crohn′s disease and Johne′s disease: Common neural and immune pathogenicities. J Clin Microbiol 2007;45:3883-90.
  • 21 Cernicchiaro N, Wells SJ, Janagama H, Sreevatsan S. Influence of type of culture medium on characterization of Mycobacterium avium subsp. paratuberculosis subtypes. J Clin Microbiol 2008;46:145-9.
  • 22 Vary PH, Andersen PR, Green E, Hermon-Taylor J, McFadden JJ. Use of highly specific DNA probes and the polymerase chain reaction to detect Mycobacterium paratuberculosis in Johne′s disease. J Clin Microbiol 1990;28:933-7.
  • 23 Thwaites GE, Simmons CP, Than Ha Quyen N, Thi Hong Chau T, Phuong Mai P, Thi Dung N, et al. Pathophysiology and prognosis in vietnamese adults with tuberculous meningitis. J Infect Dis 2003;188:1105-15.
  • 24 Singh AV, Singh SV, Makharia GK, Singh PK, Sohal JS. Presence and characterization of Mycobacterium avium subspecies paratuberculosis from clinical and suspected cases of Crohn′s disease and in the healthy human population in India. Int J Infect Dis 2008;12:190-7.
  • 25 Moss MT, Sanderson JD, Tizard ML, Hermon-Taylor J, el-Zaatari FA, Markesich DC, et al. Polymerase chain reaction detection of Mycobacterium paratuberculosis and Mycobacterium avium subsp silvaticum in long term cultures from Crohn′s disease and control tissues. Gut 1992;33:1209-13.
  • 26 Murray A, Oliaro J, Schlup MM, Chadwick VS. Mycobacterium paratuberculosis and inflammatory bowel disease: Frequency distribution in serial colonoscopic biopsies using the polymerase chain reaction. Microbios 1995;83:217-28.
  • 27 Collins MT, Lisby G, Moser C, Chicks D, Christensen S, Reichelderfer M, et al. Results of multiple diagnostic tests for Mycobacterium avium subsp. paratuberculosis in patients with inflammatory bowel disease and in controls. J Clin Microbiol 2000;38:4373-81.
  • 28 Frank TS, Cook SM. Analysis of paraffin sections of Crohn′s disease for Mycobacterium paratuberculosis using polymerase chain reaction. Mod Pathol 1996;9:32-5.
  • 29 Pierce ES. Where Are All the Mycobacterium avium Subspecies paratuberculosis in patients with Crohn′s Disease? PLoS Pathog 2009;5:e1000234.
  • 30 Juste RA, Elguezabal N, Garrido JM, Pavon A, Geijo MV, Sevilla I, et al. On the prevalence of M. avium subspecies paratuberculosis DNA in the blood of healthy individuals and patients with inflammatory bowel disease. PLoS One 2008;3:e2537.
  • 31 Nikkari S, McLaughlin IJ, Bi W, Dodge DE, Relman DA. Does blood of healthy subjects contain bacterial ribosomal DNA? J Clin Microbiol 2001;39:1956-9.
  • 32 Juste RA, Elguezabal N, Pavón A, Garrido JM, Geijo M, Sevilla I, et al. Association between Mycobacterium avium subsp. paratuberculosis DNA in blood and cellular and humoral immune response in inflammatory bowel disease patients and controls. Int J Infect Dis 2009;13:247-54.
  • 33 Krajden M. Bridging the gap between analytical and clinical validation. In: Lorincz AT, editor. Nucleic Acid Testing for Human Disease. Boca Raton, FL: Taylor and Francis; 2005.
  • 34 Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn′s disease. Nature 2001;411:603-6.
  • 35 Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn′s disease. Nature 2001;411:599-603.
  • 36 Cosnes J. Tobacco and IBD: Relevance in the understanding of disease mechanisms and clinical practice. Best Pract Res Clin Gastroenterol 2004;18:481-96.
  • 37 Richter E, Greinert U, Kirsten D, Rüsch-Gerdes S, Schlüter C, Duchrow M, et al. Assessment of mycobacterial DNA in cells and tissues of mycobacterial and sarcoid lesions. Am J Respir Crit Care Med 1996;153:375-80.
  • 38 Sechi LA, Paccagnini D, Salza S, Pacifico A, Ahmed N, Zanetti S. Mycobacterium avium subspecies paratuberculosis bacteremia in type 1 diabetes mellitus: An infectious trigger? Clin Infect Dis 2008;46:148-9.
  • 39 Greenstein RJ, Su L, Juste RA, Brown ST. On the action of cyclosporine A, rapamycin and tacrolimus on M. avium including subspecies paratuberculosis. PLoS One 2008;3:e2496.
  • 40 Runyon EH. Ten mycobacterial pathogens. Tubercle 1974;55:235-40.
  • 41 Collins DM, Gabric DM, de Lisle GW. Identification of two groups of Mycobacterium paratuberculosis strains by restriction endonuclease analysis and DNA hybridization. J Clin Microbiol 1990;28:1591-6.
  • 42 Harris NB, Barletta RG. Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine. Clin Microbiol Rev 2001;14:489-512.
  • 43 Roiz MP, Palenque E, Guerrero C, Garcia MJ. Use of restriction fragment length polymorphism as a genetic marker for typing Mycobacterium avium strains. J Clin Microbiol 1995;33:1389-91.
  • 44 Whittington R, Marsh I, Choy E, Cousins D. Polymorphisms in IS1311, an insertion sequence common to Mycobacterium avium and M. avium subsp. paratuberculosis, can be used to distinguish between and within these species. Mol Cell Probes 1998;12:349-58.
  • 45 Thorel MF, Drichevsky M, Le´vy-Fre´bault VV. Numerical taxonomy of mycobactin-dependent Mycobacteria, amended description of Mycobacterium avium, and description of Mycobacterium avium subsp. avium subsp. nov., Mycobacterium avium subsp. paratuberculosis subsp. nov., and Mycobacterium avium subsp. silvaticum subsp. nov. Int J Syst Bacteriol 1990;40:254-60.
  • 46 World Health Organization. Pathogenic Mycobacteria in Water: A Guide to Public Health Consequences, Monitoring and Management. In: Pedley S, Bartram J, Rees G, Dufour A, Cotruvo J, editors. London, UK: IWA Publishing, 2004. p. 259.
  • 47 Moreira AR, Paolicchi F, Morsella C, Zumarraga M, Cataldi A, Fabiana B, et al. Distribution of IS900 restriction fragment length polymorphism types among animal Mycobacterium avium subsp. paratuberculosis isolates from Argentina and Europe. Vet Microbiol 1999;70:251-9.
  • 48 Singh S, Gopinath K. Non-tuberculous Mycobacteria in TB-endemic countries: Are we neglecting the danger? PLoS Negl Trop Dis, 2010; 4:e615.