CC BY-NC-ND 4.0 · J Lab Physicians 2010; 2(01): 042-043
DOI: 10.4103/0974-2727.66707
Case Report

Myeloperoxidase-antineutrophil Cytoplasmic Antibodies with Cytoplasmic Fluorescence Pattern

Seema Chhabra
Department of Immunopathology, PGIMER, Chandigarh, India
,
Ranjana Walker Minz
Department of Immunopathology, PGIMER, Chandigarh, India
,
Lekha Goyal
Department of Immunopathology, PGIMER, Chandigarh, India
,
Nidhi Sharma
Department of Immunopathology, PGIMER, Chandigarh, India
› Author Affiliations
Source of Support: Nil

ABSTRACT

We report here two rare cases of myeloperoxidase–antineutrophil cytoplasmic antibody (MPO-ANCA)-positive Wegener’s granulomatosis (limited variant) which deceptively produced a cytoplasmic (C-ANCA) pattern on indirect immunofluorescence.



Publication History

Article published online:
29 January 2020

© 2010.

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 
  • REFERENCES

  • 1 Lüdemann J, Utecht B, Gross WL. Anti-neutrophil cytoplasm antibodies in Wegener′s granulomatosis recognize an elastinolytic enzyme. J Exp Med 1990;171:357-62.
  • 2 Gross WL, Schmitt WH, Csernok E. ANCA and associated diseases: Immunodiagnostic and pathogenetic aspects. Clin Exp Immunol 1993;91:1-12.
  • 3 Savige J, Dimech W, Fritzler M, Goeken J, Hagen EC, Jennette JC, et al. Addendum to the International Consensus Statement on testing and reporting of antineutrophil cytoplasmic antibodies: Quality control guidelines, comments, and recommendations for testing in other autoimmune diseases. Am J Clin Pathol 2003;120:312-8.
  • 4 Segelmark M, Baslund B, Wieslander J. Some patients with anti-myeloperoxidase autoantibodies have a C-ANCA pattern. Clin Exp Immunol 1994;96:458-65.
  • 5 Bajema IM, Hagen EC, Hermans J, Noël LH, Waldherr R, Ferrario F, et al. Kidney biopsy as a predictor for renal outcome in ANCA-associated necrotizing glomerulonephritis. Kidney Int 1999;56:1751-8.
  • 6 Flores-Suárez LF, Cabiedes J, Villa AR, van der Woude FJ, Alcocer-Varela J. Prevalence of antineutrophil cytoplasmic autoantibodies in patients with tuberculosis. Rheumatology 2003;42:223-9.
  • 7 Teixeira L, Mahr A, Jaureguy F, Noël LH, Nunes H, Lefort A, et al. Low seroprevalence and poor specificity of antineutrophil cytoplasmic antibodies in tuberculosis. Rheumatology 2005;44:247-50.
  • 8 Pradhan V, Badakere SS, Shankar Kumar U. Increased incidence of cytoplasmic ANCA (cANCA) and other autoantibodies in leprosy patients from western India. Lepr Rev 2004;75:50-6.
  • 9 Gordon C, Luqmani R, Fields P, Howie AJ, Emery P. Two cases of Wegener′s tuberculosis. Br J Rheumatol 1993;32:143-9.