Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(04): 187-191
DOI: 10.4103/0971-5851.95138
ORIGINAL ARTICLE

Epidemiology of musculoskeletal tumors in Shiraz, south of Iran

Saeed Solooki
Department of Orthopedic Surgery, Research Center for Bone and Joint Diseases, Chamran Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
,
Amir Reza Vosoughi
Department of Orthopedic Surgery, Research Center for Bone and Joint Diseases, Chamran Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
,
Vahid Masoomi
Department of Orthopedic Surgery, Research Center for Bone and Joint Diseases, Chamran Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
› Author Affiliations
› Further Information
  PDF Download Permissions and Reprints

Abstract

Background: Musculoskeletal tumors are rare, but their descriptive data in any region are important to reduce mortality rate and improve their management. Materials and Methods: Retrospectively, 426 pathologic reports from 1997 to 2008 were reviewed in Shiraz University Orthopedic Hospitals which are the main referral centers for musculoskeletal tumors in south of Iran. We collected and analyzed data on age, gender, anatomical site, and histopathologic types of musculoskeletal tumors. Results: Of the 426 cases, 60.1% were men and 39.9% were women. The commonest malignant bone tumors were osteosarcoma (89; 50.6%), metastasis (30; 17.0%), Ewing′s sarcoma (28; 15.9%), and chondrosarcoma (14; 8.0%). The most frequent benign bone tumors were osteochondroma (136; 63.9%), enchondroma (23; 10.8%), giant cell tumor (21; 9.9%), and osteoid osteoma (14; 6.6%). The femur was the most commonly involved site in musculoskeletal tumors. It was followed by the tibia in benign tumors and the humerus in malignant ones. Metastasis (28; 32.6%), soft tissue tumors (18; 20.9%), osteochondroma (10; 11.6%), and osteosarcoma (9; 10.5%) were the most diagnosed bone lesions in patients older than 40. Conclusion: There are no significant changes in epidemiology of musculoskeletal tumors in Shiraz, south of Iran, in comparison with other parts of the world.

Keywords

Benign - bone - Iran - malignancy - musculoskeletal - Shiraz - tumor


Publication History

Article published online:
06 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res 2006;12:6243s-9s.
  • 2 Lewis VO. What′s new in musculoskeletal oncology. J Bone Joint Surg Am 2007;89:1399-407.
  • 3 Fletcher CD, Unni KK, Mertens F, editors. Pathology and genetics of tumours of soft tissue and bone. Vol. 5 of World Health Organization classification of tumours. Lyon, France: IARC Press, 2002.
  • 4 Stiller CA, Bielack SS, Jundt G, Steliarova-Foucher E. Bone tumours in European children and adolescents, 1978-1997. Report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006;42:2124-35.
  • 5 Bramer JA, Somford MP. The epidemiology of primary skeletal malignancy. Orthop Trauma 2010;24:247-51.
  • 6 Parkin DM, Stiller CA, Nectoux J. International variations in the incidence of childhood bone tumours. Int J Cancer 1993;53:371-6.
  • 7 Eyre R, Feltbower RG, Mubwandarikwa E, Eden TO, McNally RJ. Epidemiology of bone tumours in children and young adults. Pediatr Blood Cancer 2009;53:941-52.
  • 8 Shah SH, Muzaffar S, Soomro IN, Pervez S, Hasan SH. Clinico-morphological pattern and frequency of bone cancer. J Pak Med Assoc 1999;49:110-2.
  • 9 Omololu AB, Ogunbiyi JO, Ogunlade SO, Alonge TO, Adebisi A, Akang EE. Primary malignant bone tumour in a tropical African University teaching hospital. West Afr J Med 2002;21:291-3.
  • 10 Rao VS, Pai MR, Rao RC, Adhikary MM. Incidence of primary bone tumours and tumour like lesions in and around Dakshina Kannada district of Karnataka. J Indian Med Assoc 1996;94:103-4.
  • 11 Yeole BB, Jussawalla DJ. Descriptive epidemiology of bone cancer in greater Bombay. Indian J Cancer 1998;35:101-6.
  • 12 Damron TA, Ward WG, Stewart A. Osteosarcoma, chondrosarcoma, and Ewing′s sarcoma: National Cancer Data Base Report. Clin Orthop Relat Res 2007;459:40-7.
  • 13 Ritter J, Bielack SS. Osteosarcoma. Ann Oncol 2010;21 Suppl 7:vii320-5.
  • 14 Buckley JD, Pendergrass TW, Buckley CM, Pritchard DJ, Nesbit ME, Provisor AJ, et al. Epidemiology of osteosarcoma and Ewing′s sarcoma in childhood: A study of 305 cases by the Children′s Cancer Group. Cancer 1998;83:1440-8.
  • 15 Baena-Ocampo Ldel C, Ramirez-Perez E, Linares-Gonzalez LM, Delgado-Chavez R. Epidemiology of bone tumors in Mexico City: Retrospective clinicopathologic study of 566 patients at a referral institution. Ann Diagn Pathol 2009;13:16-21.
  • 16 Blackwell JB, Threlfall TJ, McCaul KA. Primary malignant bone tumours in Western Australia, 1972-1996. Pathology 2005;37:278-83.
  • 17 Settakorn J, Lekawanvijit S, Arpornchayanon O, Rangdaeng S, Vanitanakom P, Kongkarnka S, et al. Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases. J Med Assoc Thai 2006;89:780-7.
  • 18 Stiller CA, Craft AW, Corazziari I. Survival of children with bone sarcoma in Europe since 1978: Results from the EUROCARE study. Eur J Cancer 2001;37:760-6.
  • 19 Odetayo OO. Pattern of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria. West Afr J Med 2001;20:161-4.
  • 20 Turcotte RE. Giant cell tumor of bone. Orthop Clin North Am 2006;37:35-51.
  • 21 Heck RK. General principles of tumors. In: Canale ST, Beaty JH, editors. Campbell′s Operative Orthopaedics. 11 th ed. Philadelphia: Mosby, Elsevier: 2008. p. 775-854.