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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(03): 165-167
DOI: 10.4103/0971-5851.92821
CASE REPORT

Congenital acute megakaryocytic leukemia

N B Mathur
Department of Pediatrics, Maulana Azad Medical College, Delhi, India
,
Neha Joshi
Department of Pediatrics, Maulana Azad Medical College, Delhi, India
,
T Singh
Department of Pathology, Maulana Azad Medical College, Delhi, India
,
Meeta Singh
Department of Pathology, Maulana Azad Medical College, Delhi, India
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Abstract

Congenital leukemia (CL) is an extremely rare disorder in the newborn, significant proportion of which is of myeloid origin, primarily of M4 or M5 morphology. As compared to pediatric leukemia, CL is a more aggressive disease. Acute myeloid leukemia (AML-M7) or acute megakaryocytic leukemia is a rare type of AML with an incidence of 0.5 per million per year. Median age of presentation is 6 years, and children may present with a broad variety of symptoms including low-grade fever, diarrhea, easy bruising, failure to gain weight and life-threatening conditions.

Keywords

Congenital megakaryocytic leukemia - neonate - sepsis


Publication History

Article published online:
06 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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