Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(03): 154-156
DOI: 10.4103/0971-5851.92816
CASE REPORT

Clinical and laboratory observation systemic lupus erythematosus and acute lymphocytic leukemia: An unusual case

Anu Maheshwari
Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India
,
Meenu Pandey
Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India
,
Bimbadhar Rath
Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India
,
Jagdish Chandra
Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India
,
Smita Singh
Department of Pathology, Lady Hardinge Medical College, New Delhi, India
,
Sunita Sharma
Department of Pathology, Lady Hardinge Medical College, New Delhi, India
› Author Affiliations
› Further Information
  PDF Download Permissions and Reprints

Abstract

The association of systemic lupus erythematosus (SLE) and myeloproliferative and lymphoproliferative malignancies is widely reported. There is scarce information available with regards to the association of SLE and malignancy in children. Usually, SLE precedes the onset of lymphoproliferative disease, but the neoplasia can occur earlier or even simultaneously. There are only five pediatric cases of SLE and associated acute lymphoblastic leukemia (ALL) reported in literature. All of these except one satisfied the revised American College of Rheumatology Criteria for SLE. Three of these cases developed SLE several years after successful treatment of ALL. While two cases reported had simultaneous onset of SLE and ALL, one of the cases in this two-patient series, did not fulfill ≥4 criteria for diagnosis of SLE. We present a case of a 3-year-old boy with SLE and coexistent ALL. To the best of our knowledge, only two such cases of simultaneous presentation of both these diseases are present in literature.

Keywords

Acute lymphoblastic leukemia - myeloproliferative disorder - systemic lupus erythematosus


Publication History

Article published online:
06 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Abu-Shakra M, Gladman D, Urowitz M. Malignancy in systemic lupus erythematosus. Arthritis Rheum 1996;39:1050-4.
  • 2 Sultan SM, Ioannou Y, Isenberg DA. Is there an association of malignancy with systemic lupus erythematosus? An analysis of 276 patients under longterm review. Rheumatology (Oxford) 2000;39:1147-52.
  • 3 Xu Y, Wiernik PH. Systemic lupus erythematosus and B-cell hematologic neoplasm. Lupus 2001;10:841-50.
  • 4 Vasquez S, Kavanaugh AF, Schneider NR, Wacholtz MC, Lipsky PE. Acute nonlymphocytic leukemia after treatment of systemic lupus erythematosus with immunosuppressive agents. J Rheumatol 1992;19:1625-7.
  • 5 Cammarata RJ, Rodnan GP, Jensen WN. Systemic rheumatic diseases and malignant lymphoma. Arch Intern Med 1963;111:330-7.
  • 6 Andreev VC, Zlatkov NB. Systemic lupus erythematosus and neoplasia of the lymphoreticular system. Br J Dermatol 1968;80:503-8.
  • 7 Green JA, Dawson AA, Walker W. Systemic lupus erythematosus and lymphoma. Lancet 1978;2:753-6.
  • 8 Houssiau FA, Kirkove C, Asherson RA, Hughes GR, Timothy AR. Malignant lymphoma in systemic rheumatic diseases: A report of 5 cases. Clin Exp Rheumatol 1991;9:515-8.
  • 9 Menon S, Snaith ML, Isenberg DA. The association of malignancy with SLE: An analysis of 150 patients under long-term review. Lupus 1993;2:177-81.
  • 10 Kletzel M, Melloni L, Terrez A, Rosenthal J. Systemic lupus erythematosus preceding acute lymphoblastic leukemia. J Ark Med Soc 1986;82:563-5.
  • 11 Bernard J. Complete remissions in acute leukemia. Israel J Med Sci 1965;1:1316-22.
  • 12 Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
  • 13 Saulsbury FT, Sabio H, Conrad D, Kesler RW, Levien MG. Acute leukemia with features of systemic lupus erythematosus. J Pediatr 1984;105:57-9.
  • 14 Sheehan NJ. Systemic lupus erythematosus after acute lymphobalstic leukaemia. Rheumatology (Oxford) 2002;41:113-4.
  • 15 Steinbach WJ, Sandborg CI. Development of systemic lupus erythematosus following autologous bone marrow transplant for acute lymphocytic leukemia. J Rheumatol 2001;28:1467-8.
  • 16 Al Mayouf SM, Seraihy A. Systemic lupus erythematosus following acute lymphocytic leukemia. Ann Saudi Med 2006;26:59-61.
  • 17 Boumpas DT, Tsokos GC, Mann DL, Eleftheriades EG, Harris CC, Mark GE. Increased proto-oncogene expression in peripheral blood lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis Rheum 1986;29:755-60.