CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(02): 118-121
DOI: 10.4103/0971-5851.89798
CASE REPORT

Primary extraosseous intracranial Ewing′s sarcoma: Case report and literature review

Krishnangshu Bhanja Choudhury
Department of Radiotherapy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India
,
Shyam Sharma
Department of Radiotherapy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India
,
Ramesh Kothari
Department of Radiotherapy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India
,
Anjali Majumder
Department of Radiotherapy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India
› Author Affiliations
Source of Support Nil.

Abstract

Ewing′s sarcoma / peripheral primitive neuroectodermal tumors occur most often in bone and soft tissues of children and young adults. The intracranial manifestation of the disease is rare, and when present, this is often misdiagnosed with other varieties of primary brain tumors. We report such a case of extraosseous Ewing′s sarcoma, which was initially suspected to be a case of meningioma in an 11-year-old girl.



Publication History

Article published online:
06 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Toskos M. Peripheral primitive neuroectodermal tumors. diagnosis, classification and prognosis. Perspect Pediatr Pathol 1992;16:27-98.
  • 2 Ewing J. Diffuse endothelioma of bone. Proc N Y Pathol Soc 1921; 21: 17-24.
  • 3 Falk S, Alpert M. The clinical and Roengen aspects of Ewing′s sarcoma. Am J Med Sci 1965;250:492-508.
  • 4 Bhansali SK, Desai PB. Ewing sarcoma observation on 107 cases. J Bone Joint Surg. 1963; 45: 541-553.
  • 5 Steinbok P, Flodmark O, Norman MG, Chan KW, Flyer CJ. Primary Ewing′s sarcoma of the base of the skull. Neurosurgery 1986;19:104-7.
  • 6 Dedeurwaerdere F, Giannini C, Sciot R, Rubin BP, Perilongo G, Borghi L, et al. Primary peripheral PNET / Ewing′s sarcoma of the dura: A clinicopathologic entity distinct from central PNET. Mod Pathol 2002;1:673-8.
  • 7 Jay V, Zielenska M, Lorenzana A, Drake J. An unusual cerebellar primitive neuroectodermal tumor with t(11;22) translocation: pathological and molecular analysis. Pediatr Pathol Lab Med 1999;16:119-28.
  • 8 Mazur MA, Gururangan S, Bridge JA, Cummings TJ, Mukundan S, Fuchs H, et al. Intracranial Ewing′s sarcoma. Pediatr Blood Cancer 2005;45:850-6.
  • 9 Katayma Y, Kimura S, Watanabe T, Yoshino A, Koshinaga M. Peripheral-type primitive neuroectodermal tumor arising in the tentorium: Case report. J Neurosurg 1999;90:141-4.
  • 10 Antunes NL, Lellouch-Tubiana A, Kalifa C, Delattre O, Pierre-Kahn A, Rosenblum MK. Intracranial Ewing sarcoma / ′peripheral′ primitive neuroectodermal tumor of dural origin with molecular genetic confirmation. J Neurooncol 2001;51:51-6.
  • 11 Papotti M, Abbona G, Pagani A. Primitive neuroectodermal tumor of the meninges: An histology, immunohistochemical, ultrastructural and cytogenetic study. Endocr Pathol 1998;3:275-80.
  • 12 Rorke LB, Hart MN, McLendon RE. Supratentorial primitive neuroectodermal tumor (PNET). In: Kleihues PCW, ed. Tumors of the nervous system. Lyon, France: IARC Press; 2000. p.141-4.
  • 13 Sandberg AA, Bridge JA. Updates on cytogenetics and molecular genetics of bone and soft tissue tumors: Ewing sarcoma and peripheral primitive neuroectodermal tumors. Cancer Genet Cytogenet 2000;123:1-26.
  • 14 Gu M, Antonescu CR, Guiter G, Huvos AG, Ladanyi M, Zakowski MF. Cytokeratin immunoreactivity in Ewing′s sarcoma: prevalence in 50 cases confirmed by molecular diagnostic studies. Am J Surg Pathol 2000;24:410-6.
  • 15 Fellinger EJ, Garin-Chesa P, Triche TJ, Huvos AG, Rettig WJ. Immunohistochemical analysis of Ewing′s sarcoma cell surface antigen p30 / 32MIC2. Am J Pathol 1991;139: 317-25.
  • 16 Ladanyi M, Lewis R, Garin-Chesa P, Rettig WJ, Huvos AG, Healey JH, et al. EWS rearrangement in Ewing′s sarcoma and peripheral neuroectodermal tumor: Molecular detection and correlation with cytogenetic analysis and MIC2 expression. Diagn Mol Pathol 1993;2:141-6.
  • 17 Schmidt D, Hermann C, Jurgens H, Harms D. Malignant peripheral neuroectodermal tumor and its necessary distinction from Ewing′s sarcoma: A report from Kiel pediatric tumor registry. Cancer 1991;68:2251-9.
  • 18 Dirks PB, Harris L, Hoffman HJ, Humphreys RP, Drake JM, Rutka JT. Supratentorial primitive neuroectodermal tumors in children. J Neurooncol 1996;29:75-84.
  • 19 Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA. Ewing′s sarcoma: Standard and experimental treatment options. Curr Treat Options Oncol 2009;10:126-40.
  • 20 Paulussen M, Craft AW, Lewis I, Hackshaw A, Douglas C,Dunst J, et al. Results of the EICESS-92 Study: Two randomized trials od Ewing′s sarcoma treatment - cyclosphosphamide compared with ifosfamide in standard risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients. J Clin Oncol 2008;26:4385-93.
  • 21 Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing′s sarcoma and primitive neurectodermal tumor of bone. N Engl J Med 2003;348:694-701.
  • 22 Hadfield MG, Quezado MM, Williams RL, Luo VY. Ewings family of tumors involving structures related to the central nervous system: A review. Pediatr Dev Pathol 2000;3:203-10.