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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(02): 105-108
DOI: 10.4103/0971-5851.89794
CASE REPORT

Embryonal carcinoma in androgen insensitivity syndrome

Debabrata Barmon
Department of Gynecologic Oncology, Dr. B. Borooah Cancer Institute, Guwahati, India
,
Amal Chandra Kataki
Department of Gynecologic Oncology, Dr. B. Borooah Cancer Institute, Guwahati, India
,
J D Sharma
Department of Pathology, Dr. B. Borooah Cancer Institute, Guwahati, India
,
Rahman Hafizur
Department of O&G, Sikkim Manipal Institute of Medical Sciences, Sikkim, India
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Abstract

Embryonal cell carcinoma is a rare clinical entity. We report a case of a 20-year-old patient who presented with lump lower abdomen for last two months with primary amenorrhea and poorly developed secondary sexual characteristics. Ultrasonography (USG) whole abdomen showed lower abdominal mass approximately 15΄15΄10 cm, probably neoplastic changes in intra-abdominal testis, with mild ascites, no uterus and ovaries. Fine needle aspiration cytology from the tumor mass reported the possibility of non-seminomatous germ cell tumor, possibly embryonal carcinoma. The patient received three cycles of neo-adjuvant chemotherapy (Regime Bleomycin, Etoposide and Cisplatin) followed by laparotomy, at laparotomy (L) orchidectomy with removal of tumor, (R) orchidectomy, omentectomy and appendisectomy was performed. Postoperatively the patient received two more cycles of chemotherapy of the same regime. The patient has been under close follow-up for the last three years with no evidence of disease.

Keywords

Androgen insensitivity syndrome - karyotype - masculinisation - mosaicism - virilisation


Publication History

Article published online:
06 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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