Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(01): 34-37
DOI: 10.4103/0971-5851.81888
ORIGINAL ARTICLE

The relationship between serum lipid levels and the risk of oral cancer

Jyoti G Chawda
Department of Oral Pathology, Government Dental College and Hospital, Ahmedabad, Gujrat, India
,
Shikha S Jain
Department of Oral Pathology, Government Dental College and Hospital, Ahmedabad, Gujrat, India
,
Hemali R Patel
Department of Oral Pathology, Government Dental College and Hospital, Ahmedabad, Gujrat, India
,
Nandini Chaduvula
Department of Oral Pathology, Government Dental College and Hospital, Ahmedabad, Gujrat, India
,
Kunal Patel
Pacific Dental College, Udaipur, Rajasthan, India
› Author Affiliations Source of Support Nil.
› Further Information
  PDF Download Permissions and Reprints

Abstract

Background: Lipids are the major cell membrane components essential for various biological functions including cell growth and division for the maintenance of cell integrity of normal and malignant tissues. The changes in lipid profile have long been associated with cancer. Hypocholesterolemia has been observed in patients with cancers of various organs. Therefore, a causative relationship might exist between plasma lipid levels and oral cancer patients. Aim: The objective of this study was to investigate the alterations and clinical significance of plasma lipid profiles in untreated head and neck cancer patients. Materials and Methods: A total of 30 subjects (25 oral cancer patients and 5 controls) were included. Fasting blood lipid profile including cholesterol (C), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were evaluated using spectrophotometric kits, with CHOD PAP technique. The values were then statistically analyzed using analysis of variance (ANOVA) and post hoc methods. Results: The levels of total lipids, cholesterol and HDL were significantly lower in oral cancer patients as compared to controls, but LDL and VLDL values were not significant. Conclusion: An inverse relationship was found between the lipid levels and the occurrence of oral cancer. Hence, the lower plasma lipid status may be a useful indicator to detect the initial changes seen in neoplastic process.

Keywords

CHOD PAP - hypocholesterolemia - inverse relationship - lipids - oral cancer


Publication History

Article published online:
16 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Lohe VK, Degwekar SS, Bhowate RR, Kadu RP, Dangore SB. Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse. J Oral Pathol Med 2010;39:141-8.
  • 2 Patel PS, Shah MH, Jha FP, Raval GN, Rawal RM, Patel MM et al. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer 2004;41:25-31.
  • 3 Mehrotra R, Pandya S, Chaudhary AK, Singh HP, Jaiswal RK, Singh M, et al. Lipid profile in oral submucous fibrosis. Lipids Health Dis 2009;29:1-7.
  • 4 Rose G, Shipley MJ. Plasma lipids and Mortality: a source of error. Lancet 1980;1:523-6.
  • 5 Alexopoulos CG, Blatsios B, Avgerinos A. Serum Lipids and Lipoprotein Disorders in Cancer Patients. Cancer 1987;60:3065-70.
  • 6 Kark JD, Smith AH, Hames CG. Serum retinol and the inverse relationship between serum cholesterol and cancer. Br Med J (Clin Res Ed) 1982;284:152-4.
  • 7 Halton JM, Nazir DJ, McQueen MJ, Barr RD. Blood Lipid Profiles in Children with Acute Lymphoblastic Leukemia. Cancer 1998;83:379-84.
  • 8 Wald NJ, Thompson SG, Law MR, Densem JV, Bailey A. Serum cholesterol and subsequent risk of cancer: results from the BUPA study. Br J Cancer 1989;59:936-8.
  • 9 Kritchevsky SB, Wilcosky TC, Morris DL, Truong KN, Tyroler HA. Changes in Plasma Lipid and Lipoprotein Cholesterol and Weight prior to the Diagnosis of Cancer. Cancer Res 1991;51:3198-203.
  • 10 Winn DM. Diet and nutrition in the etiology of oral cancer. Am J Clin Nutr1995;61:437s-45s.