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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2010; 31(01): 36-38
DOI: 10.4103/0971-5851.68853
CASE REPORT

Florid plasmacytosis in a case of acute myeloid leukemia: A diagnostic dilemma

Aruna Rangan
Department of Hematology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India
,
Bhavna Arora
Department of Hematology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India
,
Pooja Rangan
Department of Hematology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, India
,
Tina Dadu
Department of Hematology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India
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Abstract

The association of acute myeloid leukemia (AML) with plasmacytosis is a known, although rare event. There are very few case reports documenting an increase in the number of plasma cells at the time of AML diagnosis. Here, we present the case of a 65-year-old male diagnosed as acute myelomonocytic leukemia with exuberant plasmacytosis, which posed a difficulty in diagnosis. Paracrine interleukin-6 production by leukemic blast cells is thought to contribute to this associated reactive plasma cell proliferation.

Keywords

Acute myeloid leukemia - myeloma - plasmacytosis


Publikationsverlauf

Artikel online veröffentlicht:
19. November 2021

© 2010. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Hyun BH, Kwa D, Gabaldon H, Ashton JK. Reactive plasmacytic lesions of the bone marrow. Am J Clin Pathol 1976;65:921-8.
  • 2 Liu CT, Dahlke MB. Bone marrow findings of reactive plasmacytosis. Am J Clin Pathol 1967;48:546-51.
  • 3 Sivasankaran S, Das KV, Thomas M, Pillai R, Balaram P, Augustin J, et al. Adrenal carcinoma with reactive plasmacytosis. J Assoc Physicians India 1989;37:237-9.
  • 4 Al-Shughair N, Al-Dawsari G, Gyger M, Mohamed G, Roberts G. Clinical significance of plasmacytosis in the day+14 bone marrow of patients with acute myeloid leukaemia undergoing induction chemotherapy. J Clin Pathol 2007;60:520-3.
  • 5 Wulf GG, Jahns-Streubel G, Hemmerlein B, Bonnekessen K, Wφrmann B, Hiddemann W. Plasmacytosis in acute myeloid leukemia: Two cases of plasmacytosis and increased IL-6 production in the AML blast cells. Ann Hematol 1998;76:273-7.
  • 6 Gavarotti P, Boccadoro M, Redoglia V, Golzio F, Pileri A. Reactive plasmacytosis: Case report and review of the literature. Acta Haematol 1985;73:108-10.
  • 7 Rosenthal NS, Farhi DC. Reactive plasmacytosis and lymphocytosis in acute myeloid leukemia. Hematol Pathol 1994;8:43-51.