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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2010; 31(01): 8-17
DOI: 10.4103/0971-5851.68846
REVIEW ARTICLE

NEO adjuvant chemotherapy in breast cancer: What have we learned so far?

Nirmal V Raut
Department of Medical Oncology, Terna Sahyadri Hospital, Nerul, Navi Mumbai, India
,
Nilesh Chordiya
Department of Surgical Oncology, Terna Sahyadri Hospital, Nerul, Navi Mumbai, India
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Abstract

Neoadjuvant chemotherapy (NACT) in breast cancer has undergone continuous evolution over the last few decades to establish its role in the combined modality management of these tumors. The process of evolution is still far from over. Many questions are still lurking in the minds of oncologists treating breast cancer. This review analyzes the evidence from metaanlyses, major multiinstitutional prospective trials, retrospective institutional series and systematic reviews in breast cancer to determine the current standards and controversies in NACT. The most effective drugs, their advantages, issues and controversies in delivery as well as the criteria for response are reviewed. A summary of evidence-based consensus is presented and unresolved aspects are discussed.

Keywords

Breast cancer - neoadjuvant chemotherapy - review


Publication History

Article published online:
19 November 2021

© 2010. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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