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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2009; 30(04): 153-155
DOI: 10.4103/0971-5851.65346
CASE REPORT

Immune reconstitution inflammatory syndrome in AIDS-related non-hodgkin′s lymphoma

Uday A Phatak
Department of Medicine, Shri Siddhivinayak Ganapati Cancer Hospital, Miraj, India
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Abstract

Immune Reconstitution syndrome following antiretroviral therapy is common in HIV/AIDS patients due to boosting of immunity. A case is reported here wherein AIDS-related Non-Hodgkin′s lymphoma patient received CHOP regimen and antiretroviral therapy. Patient developed tubercular lymphadenopathy paradoxically as a manifestation of IRIS.

Keywords

AIDS-related lymphoma - HIV-IRIS - IRIS


Publication History

Article published online:
19 November 2021

© 2009. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Bartlett JG. The John Hopkins Hospital 2005-6. Guide to Medical Care of Patients with HIV infection. 12 th ed. Lippincott Williams and Wilkins Publication; 2006. p. 170.
  • 2 Leidner RS, Aboulafia DM. Recrudescent Kaposi′s sarcoma after initiation of HAART: a manifestation of immune reconstitution syndrome. AIDS Patient Care STDS 2005;19:635-44.
  • 3 Knysz B, Kuliszkiewicz-Janus M, Jeleρ M, Podlasin R, G΃adysz A. Non-Hodgkin′s lymphoma as a rare manifestation of immune reconstitution disease in HIV-1 positive patients. Postepy Hig Med Dosw (Online) 2006;60:547-51.
  • 4 Miceli MH, Maertens J, Buvι K, Grazziutti M, Woods G, Rahman M, et al. Immune Reconstitution Inflammatory Syndrome in cancer patients with pulmonary aspergillosis recovering from neutropenia: Proof of principle, description and clinical and research implications. Cancer 2007;110:112-20.
  • 5 Huruy K, Mulu A, Mengistu G, Shewa-Amare A, Akalu A, Kassu A, et al. Immune reconstitution inflammatory syndrome among HIV/AIDS patients during highly active antiretroviral therapy in Addis Ababa, Ethiopia. Jpn J Infect Dis 2008;61:205-09.
  • 6 Dhir AA, Sawant S, Dikshit RP, Parikh P, Srivastava S, Badwe R, et al. Spectrum of HIV/AIDS related cancers in India. Cancer Causes Control 2008;19:147-53.
  • 7 Crum-Cianflone N, Hullsiek KH, Marconi V, Weintrob A, Ganesan A, Barthel RV et al. trends in the incidence of cancers among HIV-infected persons and the impact of Antiretroviral therapy: a 20-year cohort study. AIDS 2009;23:41-50.
  • 8 Lim ST, Karim R, Tulpule A, Nathwani BN, Levine AM. Prognostic factors in HIV-related diffuse large-cell lymphoma: before versus after highly active antiretroviral therapy. J Clin Oncol 2005;23:8477-82.
  • 9 Bower M, McCall-Peat N, Ryan N, Davies L, Young AM, Gupta S, et al. Protease inhibitors potentiate chemotherapy-induced neutropenia. Blood 2004;104:2943-6.
  • 10 Toffoli G, Corona G, Cattarossi G, Boiocchi M, Di Gennaro G, Tirelli U, et al. Effect of highly active antiretroviral therapy (HAART) on pharmacokinetics and pharmacodynamics of doxorubicin in patients with HIV-associated non-Hodgkin′s lymphoma. Ann Oncol 2004;15:1805-9.
  • 11 Dhasmana DJ, Dheda K, Ravn P, Wilkinson RJ, Meintjes G. Immune reconstitution inflammatory syndrome in HIV-infected patients receiving antiretroviral therapy: pathogenesis, clinical manifestations and management. Drugs 2008;68:191-208.
  • 12 Beishuizen SJ, Geerlings SE. Immune reconstitution inflammatory syndrome: immunopathogenesis, risk factors, diagnosis and prevention. Neth J Med 2009;67:327-31.