CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2008; 29(04): 41-43
DOI: 10.4103/0971-5851.51408
Case Report

Congenital leukemia - A diagnostic dilemma

KP Prakash
Department of Paediatrics, Kasturba Medical College, Mangalore Karnataka 575001, India
,
ATK Rau
Department of Paediatric Haematology, Kasturba Medical College, Mangalore Karnataka 575001, India
,
ST Bhat
Department of Pathology, Kasturba Medical College, Mangalore Karnataka 575001, India
,
AR Rau
Department of Pathology, Kasturba Medical College, Mangalore Karnataka 575001, India
› Author Affiliations

Abstract

A 6 day old newborn presented with fever, lethargy, poor suck and mild hepatosplenomegaly, features suggestive of sepsis. Septic work up was negative. Peripheral smear revealed hyperleukocytosis, thrombocytopenia and presence of atypical cells. Bone marrow examination revealed increased myeloblasts. Other causes of leukemoid reaction were ruled out and a final diagnosis of congenital leukaemia was made.



Publication History

Article published online:
19 November 2021

© 2008. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Perkins SL. Hematopoietic system. In: Gilbert- Barness E (ed ). Potter′s pathology of the fetus, infant and child. 2nd ed.Elsevier 2007, Philadelphia, 1453-1514.
  • 2 Bajwa RP,Skinner R,Windebank KP,Reid MM.Demographic study of leukaemia presenting within the first three months of life in the northern health region of England. J Clin Pathol 2004;57:186- 188.
  • 3 McCoy JP Jr, Overton WR. Immunophenotyping of Congenital leukemia. Cytometry 1995;22:85-88.
  • 4 Warrier RP, Emami A, Ravindranath Y, Inoue S, Kaplan J. Perinatal Leukemia: The surface antigens, cytochemistry and cytogenetic features. Indian Pediatr 1983;20:325-333.
  • 5 Pui CH, Kalwinsky DK, Schell MJ, Mason CA, Mirro J, Dahl GV. Acute nonlymphoblastic leukemia in infants: clinical presentation and outcome. J Clin Oncol 1988;6:1008-1013.
  • 6 Resnick KS, Brod BB. Leukemia Cutis in Congenital leukemia: Analysis and review of the world literature with report of an additional case. Arch Dermatol 1993;129:1301-1306.
  • 7 Badhe PB, Sane SY. Congenital leukemia - Organ involvement in six autopsy cases. J Postgrad Med 1992;38:127.
  • 8 Felix CA, Lange BJ. Leukemia in infants. Oncologist 1999;4:225-240.
  • 9 Zipursky A. Transient leukaemia-a benign form of leukaemia in newborn infants with trisomy 21. Br J Hematol 2003;120;930-938.
  • 10 Bresters D, Reus AC, Veerman AJ et al. Congenital leukaemia-the Dutch experience and review of the literature.Br J Hematol 2002;117:513-524.
  • 11 Isaacs H Jr. Fetal and neonatal leukemia. J Pediatr Hematol Oncol 2003:25:348-361.
  • 12 Bader-Meunier B, Tchernia G, Mielot F et al. Occurrence of myeloproliferative disorder in patients with Noonan syndrome. J Pediatr 1997;130:885-889.