PDF herunterladen
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(01): 44-50
DOI: 10.4103/0971-5851.203510
Review Article

The Role of Chronic Mucosal Trauma in Oral Cancer: A Review of Literature

Hitesh Rajendra Singhvi
Department of Head and Neck Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Akshat Malik
Department of Head and Neck Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Pankaj Chaturvedi
Department of Head and Neck Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
› Institutsangaben Financial support and sponsorship Nil.
› Weitere Informationen
  als PDF herunterladen Lizenzen und Reprints

Abstract

Chronic mucosal trauma resulting from sharp teeth, dentures, faulty restoration, or implants has frequently been associated with the development of oral cancer. The definitive evidence for the same is lacking. We undertook a search using the terms – dental trauma, mucosal trauma, oral cancer, squamous cell carcinoma, risk factor, potentially malignant lesion, dental factor, mechanical irritation, dental irritation, and cancer in the following electronic databases: MEDLINE, PubMed, ScienceDirect, Cochrane Database of Systematic Reviews, and Wiley InterScience. The search yielded 788 articles. Of these articles, only 22 articles described chronic mucosal trauma as risk factors for oral cancers and were considered in this review. The review shows that chronic mucosal irritation resulting from ill-fitting dentures may be considered a risk factor for the development of oral cancer, such cancers occur commonly over the lateral border of the tongue. However, no association has been proven between the duration of denture use and cancer formation. In patients without any addiction, such cancers occur more frequently in females. These cancers may present with an early nodal disease but their prognosis and outcomes have not been studied separately till now.

Keywords

Dental trauma - etiology - mucosal trauma - oral cancer - risk factor - squamous cell carcinoma


Publikationsverlauf

Artikel online veröffentlicht:
06. Juli 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F.GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr. [Last accessed on 2016 Nov 20].
  • 2 Pednekar MS, Gupta PC, Yeole BB, Hébert JR. Association of tobacco habits, including bidi smoking, with overall and site-specific cancer incidence: Results from the Mumbai cohort study. Cancer Causes Control 2011;22:859-68.
  • 3 Radoï L, Luce D. A review of risk factors for oral cavity cancer: The importance of a standardized case definition. Community Dent Oral Epidemiol 2013;41:97-109, e78-91.
  • 4 Guha N, Warnakulasuriya S, Vlaanderen J, Straif K. Betel quid chewing and the risk of oral and oropharyngeal cancers: A meta-analysis with implications for cancer control. Int J Cancer 2014;135:1433-43.
  • 5 Franco EL, Kowalski LP, Oliveira BV, Curado MP, Pereira RN, Silva ME, et al. Risk factors for oral cancer in Brazil: A case-control study. Int J Cancer 1989;43:992-1000.
  • 6 Zheng TZ, Boyle P, Hu HF, Duan J, Jian PJ, Ma DQ, et al. Dentition, oral hygiene, and risk of oral cancer: A case-control study in Beijing, people's republic of China. Cancer Causes Control 1990;1:235-41.
  • 7 Marshall JR, Graham S, Haughey BP, Shedd D, O'Shea R, Brasure J, et al. Smoking, alcohol, dentition and diet in the epidemiology of oral cancer. Eur J Cancer B Oral Oncol 1992;28B: 9-15.
  • 8 Manoharan S, Nagaraja V, Eslick GD. Ill-fitting dentures and oral cancer: A meta-analysis. Oral Oncol 2014;50:1058-61.
  • 9 Sato T. A study on effect of mechanical irritation in development and progression of tongue cancer. Kokubyo Gakkai Zasshi 1995;62:532-50.
  • 10 Kawanishi S, Hiraku Y, Pinlaor S, Ma N. Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem 2006;387:365-72.
  • 11 Kundu JK, Surh YJ. Inflammation: Gearing the journey to cancer. Mutat Res 2008;659:15-30.
  • 12 Keibel A, Singh V, Sharma MC. Inflammation, microenvironment, and the immune system in cancer progression. Curr Pharm Des 2009;15:1949-55.
  • 13 Perry BJ, Zammit AP, Lewandowski AW, Bashford JJ, Dragovic AS, Perry EJ, et al. Sites of origin of oral cavity cancer in nonsmokers vs. smokers: Possible evidence of dental trauma carcinogenesis and its importance compared with human papillomavirus. JAMA Otolaryngol Head Neck Surg 2015;141:5-11.
  • 14 Velly AM, Franco EL, Schlecht N, Pintos J, Kowalski LP, Oliveira BV, et al. Relationship between dental factors and risk of upper aerodigestive tract cancer. Oral Oncol 1998;34:284-91.
  • 15 Lockhart PB, Norris CM Jr., Pulliam C. Dental factors in the genesis of squamous cell carcinoma of the oral cavity. Oral Oncol 1998;34:133-9.
  • 16 Kruse AL, Bredell M, Grätz KW. Oral squamous cell carcinoma in non-smoking and non-drinking patients. Head Neck Oncol 2010;2:24.
  • 17 Rosenquist K. Risk factors in oral and oropharyngeal squamous cell carcinoma: A population-based case-control study in Southern Sweden. Swed Dent J Suppl 2005;179:1-66.
  • 18 Rotundo LD, Toporcov TN, Biazevic GH, de Carvalho MB, Kowalski LP, Antunes JL. Are recurrent denture-related sores associated with the risk of oral cancer? A case control study. Rev Bras Epidemiol 2013;16:705-15.
  • 19 Vaccarezza GF, Antunes JL, Michaluart-Júnior P. Recurrent sores by ill-fitting dentures and intra-oral squamous cell carcinoma in smokers. J Public Health Dent 2010;70:52-7.
  • 20 Thumfart W, Weidenbecher M, Waller G, Pesch HG. Chronic mechanical trauma in the aetiology of oro-pharyngeal carcinoma. J Maxillofac Surg 1978;6:217-21.
  • 21 Campbell BH, Mark DH, Soneson EA, Freije JE, Schultz CJ. The role of dental prostheses in alveolar ridge squamous carcinomas. Arch Otolaryngol Head Neck Surg 1997;123:1112-5.
  • 22 Young TB, Ford CN, Brandenburg JH. An epidemiologic study of oral cancer in a statewide network. Am J Otolaryngol 1986;7:200-8.
  • 23 Bundgaard T, Wildt J, Frydenberg M, Elbrønd O, Nielsen JE. Case-control study of squamous cell cancer of the oral cavity in Denmark. Cancer Causes Control 1995;6:57-67.
  • 24 Schildt EB, Eriksson M, Hardell L, Magnuson A. Oral infections and dental factors in relation to oral cancer: A Swedish case – Control study. Eur J Cancer Prev 1998;7:201-6.
  • 25 Talamini R, Vaccarella S, Barbone F, Tavani A, La Vecchia C, Herrero R, et al. Oral hygiene, dentition, sexual habits and risk of oral cancer. Br J Cancer 2000;83:1238-42.
  • 26 Alburqueque R, Lépez-Lépez J, Marí-Roig A, Jané-Salas E, Chimenos-Küstner E, Santos JR. Relationship between squamous cell carcinoma of the anterior two thirds of the tongue and removable denture use: A pioneer study in a Portuguese population. Braz Dent J 2011;22:410-4.
  • 27 Wiseman SM, Swede H, Stoler DL, Anderson GR, Rigual NR, Hicks WL Jr., et al. Squamous cell carcinoma of the head and neck in nonsmokers and nondrinkers: An analysis of clinicopathologic characteristics and treatment outcomes. Ann Surg Oncol 2003;10:551-7.
  • 28 Dahlstrom KR, Little JA, Zafereo ME, Lung M, Wei Q, Sturgis EM. Squamous cell carcinoma of the head and neck in never smoker-never drinkers: A descriptive epidemiologic study. Head Neck 2008;30:75-84.
  • 29 Jainkittivong A, Aneksuk V, Langlais RP. Oral mucosal conditions in elderly dental patients. Oral Dis 2002;8:218-23.
  • 30 Zomorodian K, Haghighi NN, Rajaee N, Pakshir K, Tarazooie B, Vojdani M, et al. Assessment of Candida species colonization and denture-related stomatitis in complete denture wearers. Med Mycol 2011;49:208-11.
  • 31 Hooper SJ, Wilson MJ, Crean SJ. Exploring the link between microorganisms and oral cancer: A systematic review of the literature. Head Neck 2009;31:1228-39.
  • 32 Nishimura Y, Maeda H, Hattori M, Azumaya F, Muramatsu I, Kameyama Y, et al. Human papillomavirus infection in the oral cavity of denture wearers. Nihon Hotetsu Shika Gakkai Zasshi 2004;48:713-22.
  • 33 Piemonte ED, Lazos JP, Brunotto M. Relationship between chronic trauma of the oral mucosa, oral potentially malignant disorders and oral cancer. J Oral Pathol Med 2010;39:513-7.
  • 34 Schache A, Thavaraj S, Kalavrezos N. Osseointegrated implants: A potential route of entry for squamous cell carcinoma of the mandible. Br J Oral Maxillofac Surg 2008;46:397-9.
  • 35 Abu El-Naaj I, Trost O, Tagger-Green N, Trouilloud P, Robe N, Malka G, et al. Peri-implantitis or squamous cell carcinoma? Rev Stomatol Chir Maxillofac 2007;108:458-60.
  • 36 Bhatavadekar NB. Squamous cell carcinoma in association with dental implants: An assessment of previously hypothesized carcinogenic mechanisms and a case report. J Oral Implantol 2012;38:792-8.
  • 37 Basker RM, Sturdee DW, Davenport JC. Patients with burning mouths. A clinical investigation of causative factors, including the climacteric and diabetes. Br Dent J 1978;145:9-16.
  • 38 Kallus T. Evaluation of the toxicity of denture base polymers after subcutaneous implantation in guinea pigs. J Prosthet Dent 1984;52:126-34.
  • 39 Ali A, Bates JF, Reynolds AJ, Walker DM. The burning mouth sensation related to the wearing of acrylic dentures: An investigation. Br Dent J 1986;161:444-7.
  • 40 Giunta JL, Grauer I, Zablotsky N. Allergic contact stomatitis caused by acrylic resin. J Prosthet Dent 1979;42:188-90.