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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2016; 37(02): 70-73
DOI: 10.4103/0971-5851.180137
ORIGINAL ARTICLE

Incidence of bone metastasis in carcinoma buccal mucosa

Virendra Bhandari
Department of Radiation Oncology, Roentgen - SAIMS Radiation Oncology Centre, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
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Abstract

Introduction: Head and neck cancer is a leading health problem in India due to the habit of chewing tobacco and bad oral and dental hygiene. Carcinoma buccal mucosa is more common and is 2.5% of all malignancies at our center. Most of the patients present in stage III and IV and the survival in these cases is not very good. Bone metastasis in advanced cases of carcinoma buccal mucosa is rarely reported in the world literature. Materials and Methods: We present here cases developing bone metastasis in carcinoma buccal mucosa in last 5 years. These patients were young with loco-regionally advanced disease where bone metastasis developed within 1-year of definitive treatment. Results: The flat bones and vertebrae were mainly involved and the survival was also short after diagnosis of metastasis despite the treatment with local Radiotherapy and chemotherapy. Conclusion: The exact cause of metastasis cannot be proved, but the probability of subclinical seedling of malignant cells before the eradication of the primary tumor should be considered along with advanced local and nodal disease with high grade of tumor.

Keywords

Bone metastasis - buccal mucosa - squamous carcinoma


Publication History

Article published online:
12 July 2021

© 2016. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 National Cancer Registry Programme, ICMR. Three Year Report of PBCRs; 2006-2008.
  • 2 Borenstein M. The case for confidence intervals in controlled clinical trials. Control Clin Trials 1994;15:411-28.
  • 3 Bhandari V. Bone metastasis from head and neck cancer-case reports. J Case Rep Oncol Ther 2003;3:28-9.
  • 4 Ferlito A, Shaha AR, Silver CE, Rinaldo A, Mondin V. Incidence and sites of distant metastases from head and neck cancer. ORL J Otorhinolaryngol Relat Spec 2001;63:202-7.
  • 5 Marioni G, Blandamura S, Calgaro N, Ferraro SM, Stramare R, Staffieri A, et al. Distant muscular (gluteus maximus muscle) metastasis from laryngeal squamous cell carcinoma. Acta Otolaryngol 2005;125:678-82.
  • 6 Vikram B, Strong EW, Shah JP, Spiro R. Failure at distant sites following multimodality treatment for advanced head and neck cancer. Head Neck Surg 1984;6:730-3.
  • 7 Pichi B, Marchesi P, Manciocco V, Ruscito P, Pellini R, Cristalli G, et al. Carcinoma of the buccal mucosa metastasizing to the talus. J Craniofac Surg 2009;20:1142-5.
  • 8 Talmi YP, Cotlear D, Waller A, Horowitz Z, Adunski A, Roth Y, et al. Distant metastases in terminal head and neck cancer patients. J Laryngol Otol 1997;111:454-8.
  • 9 Kotwall C, Sako K, Razack MS, Rao U, Bakamjian V, Shedd DP. Metastatic patterns in squamous cell cancer of the head and neck. Am J Surg 1987;154:439-42.
  • 10 Mathew BS, Jayasree K, Madhavan J, Nair MK, Rajan B. Skeletal metastases and bone marrow infiltration from squamous cell carcinoma of the buccal mucosa. Oral Oncol 1997;33:454-5.
  • 11 Wenzel S, Sagowski C, Kehrl W, Metternich FU. The prognostic impact of metastatic pattern of lymph nodes in patients with oral and oropharyngeal squamous cell carcinomas. Eur Arch Otorhinolaryngol 2004;261:270-5.
  • 12 Shingaki S, Nomura T, Takada M, Kobayashi T, Suzuki I, Nakajima T. The impact of extranodal spread of lymph node metastases in patients with oral cancer. Int J Oral Maxillofac Surg 1999;28:279-84.
  • 13 Bhandari V, Jain RK. A retrospective study of incidence of bone metastasis in head and neck cancer. J Cancer Res Ther 2013;9:90-3.
  • 14 Halperin EC. Overpriced technology in radiation oncology. Int J Radiat Oncol Biol Phys 2000;48:917-8.
  • 15 Siegel JE, Weinstein MC, Russell LB, Gold MR. Recommendations for reporting cost-effectiveness analyses. Panel on Cost-Effectiveness in Health and Medicine. JAMA 1996;276:1339-41.
  • 16 Pietropaoli MP, Damron TA, Vermont AI. Bone metastases from squamous cell carcinoma of the head and neck. J Surg Oncol 2000;75:136-41.